Publications

2019 Journal Articles

Liquid-liquid phase separation and fibrillization of tau are independent processes with overlapping conditions
Y. Lin, Y. Fichou, Z. Zeng, N. Y. Hu, and S. Han. Biorxiv (2019)
DOI: 10.1101/702126

Electron Spin Density Matching for Cross-Effect Dynamic Nuclear Polarization
Y. Li, A. Equbal, K. Tagami, and S. Han. Chem. Commun. (2019)
DOI: 10.1039/C9CC03499D

Protein shapes at the core of chronic traumatic encephalopathy
Y. Fichou and S. Han. Nature Struct. Mol. Biol. (2019)
DOI: 10.1038/s41594-019-0221-2

Biradical rotamer states tune electron J coupling and MAS dynamic nuclear polarization enhancement
K. Tagami, A. Equbal, I. Kaminker, B. Kirtman, and S. Han Solid State Nucl. Mag. Res. (2019)
DOI: /10.1016/j.ssnmr.2019.04.002

Proteorhodopsin Function is Primarily Mediated by Oligomerization in Different Micellar Surfactant Solutions
M. N. Idso, N. R. Baxter, S. Narayanan, E. Chang, J. M. Fisher, B. F. Chmelka, and S. Han J. Phys. Chem. B (2019)
DOI: 10.1021/acs.jpcb.9b00922

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
Y. Lin, J. McCarty, J. N. Rauch, K. T. Delaney, K. S. Kosik, G. H. Fredrickson, J.-E. Shea, S. Han. eLife, 8 (2019), e42571
DOI: 10.7554/eLife.42571

Anomalous solute diffusivity in ionic liquids: Label-free visualization and physical origins
A. V. Bayles, C. S. Valentine, T. Überrück, S. P. O. Danielsen, S. Han, M. E. Helgeson, T. M. Squires. Phys. Rev. X (2018).
https://journals.aps.org/prx/accepted/60079K82Icf1d50f43181462e35142b9f0b4dc4c3

Cross-Effect Dynamic Nuclear Polarization Explained: Polarization, Depolarization, and Oversaturation
A. Equbal, A. Leavesley, S. K. Jain, S. Han. J. Phys. Chem. Lett., 10 (2019), 548-558.
DOI: 10.1021/acs.jpclett.8b02834
Content of this publication inspired design of cover art of entailing journal issue.
https://pubs.acs.org/toc/jpclcd/10/3

2019 Book Chapter

Methods in Enzymology: Biological NMR Part B
Vol. 615, Elsevier Inc. (2019)

Chapter Five - Overhauser Dynamic Nuclear Polarization for the Study of Hydration Dynamics, Explained
J. M. Franck and S. Han
DOI: 10.1016/bs.mie.2018.09.024

2018 Journal Articles

Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities
A. Leavesley, I. Kaminker, S. Han. eMagRes, 7 (2018), 133-154.
DOI: 10.1002/9780470034590.emrstm1564
Included as part of the "Handbook of High Frequency Dynamic Nuclear Polarization NMR" series.

Cofactors are essential constituents of stable and seeding-active tau fibrils
Y. Fichou, Y. Lin, J. N. Rauch, M. Vigers, Z. Zeng, M. Srivastava, T. J. Keller, J. H. Freed, K. S. Kosik, S. Han. Proc. Nat. Acad. Sci., 115 (52) (2018), 13234-13239.
DOI: 10.1073/pnas.1810058115
Highlighted in the UC Santa Barbara Current:
http://www.news.ucsb.edu/2018/019293/three-player-game

Effect of nitroxide spin probes on the transport properties of Nafion membranes
T. Überrück, O. Neudert, K.-D. Kreuer, B. Blümich, J. Granwehr, S. Stapf, S. Han. Phys. Chem. Chem. Phys., 20 (2018), 26660-26674.
DOI: 10.1039/C8CP04607G

Maximizing NMR signal per unit time by facilitating the e-e-n cross effect DNP rate
A. Leavesley, S. Jain, I. Kaminker, H. Zhang, S. Rajca, A. Rajca, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 27646-27654.
DOI: 10.1039/C8CP04909B. PMID: 30375593
Selected 2018 PCCP Hot Article

Tuning nuclear depolarization under MAS by electron T1e
A. Lund, A. Equibal, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 23976-23987.
DOI: 10.1039/C8CP04167A. PMID: 30211922. PMCID: PMC6208319
Selected 2018 PCCP Hot Article

Heterogeneity of network structure and water dynamics in ?-carrageenan gels probed by nanoparticle diffusometry
D. de Kort, E. Schuster, F. Hoeben, R. Barnes, M. Emondts, H. Janssen, N. Lorén, S. Han, H. van As, J. van Duynhoven. Langmuir, 34 (37) (2018), 11110-11120.
DOI: 10.1021/acs.langmuir.8b01052

Multi-step phase-cycling in a free-electron laser-powered pulsed electron paramagnetic resonance spectrometer
C. B. Wilson, S. Aronson, J. A. Clayton, S. J. Glaser, S. Han, M. S. Sherwin. Phys. Chem. Chem. Phys., 20 (2018), 18097-18109.
DOI: 10.1039/C8CP01876F

Amplification of Dynamic Nuclear Polarization at 200 GHz by Arbitrary Pulse Shaping of the Electron Spin Saturation Profile
I. Kaminker, S. Han. J. Phys. Chem. Lett., 9 (11) (2018), 3110-3115.
DOI: 10.1021/acs.jpclett.8b01413

Tuning conformation and properties of peptidomimetic backbones through dual N/C?-substitution
R. Kaminker, I. Kaminker, W. R. Gutekunst, Y. Luo, S. Lee, J. Niu, S. Han, C. J. Hawker. Chem. Comm., 54 (41) (2018), 5237-5240.
DOI: 10.1039/C8CC01356J

Truncated Cross Effect Dynamic Nuclear Polarization: An Overhauser Effect Doppelgänger
A. Equbal, Y. Li, A. Leavesley, S. Huang, S. Rajca, A. Rajca, S. Han, J. Phys. Chem. Lett., 9 (9) (2018), 2175-2180.
DOI: 10.1021/acs.jpclett.8b00751

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer’s disease filaments
Y. Fichou, M. Vigers, A. K. Goring, N. A. Eschmann, S. Han, Chem. Commun., 54 (36) (2018), 4573-4576.
PMID: 29664486
DOI: 10.1039/C8CC01355Aa

Quantitative analysis of zero-field splitting parameter distributions in Gd(III) complexes
J. A. Clayton, K. Keller, M. Qi, J. Wegner, V. Koch, H. Hintz, A. Godt, S. Han, G. Jeschke, M. S. Sherwin, M. Yulikov, Phys. Chem. Chem. Phys., 20 (15) (2018), 10470-10492.
DOI: 10.1039/c7cp08507a. PMID: 29617015. PMCID: PMC6026474.

Functionally Active Membrane Proteins Incorporated in Mesostructured Silica Films
J. P. Jahnke, M. N. Idso, S. Hussain, M. J. N. Junk, J. M. Fisher, D. D. Phan, S. Han, B. F. Chmelka, J. Am. Chem. Soc., 140 (11) (2018), 3892-3906.
DOI:10.1021/jacs.7b06863 PMID: 29533066.

Effect of Water/Glycerol Polymorphism on Dynamic Nuclear Polarization
A. Leavesley, C. B. Wilson, M. Sherwin, S. Han, Phys. Chem. Chem. Phys, 20 (15) (2018), 9897-9903.
DOI:10.1039/C8CP00358K

Reversal of Paramagnetic Effects by Electron Spin Saturation
S. K. Jain, T. A. Siaw, A. Equbal, C. B. Wilson, I. Kaminker, S. Han, J. Phys. Chem. C, 122 (10) (2018), 5578-5589.
DOI:10.1021/acs.jpcc.8b00312

Surface Chemical Heterogeneity Modulates Silica Surface Hydration
A. M. Schrader, J. I. Monroe, R. Sheil, H. A. Dobbs, T. J. Keller, Y. Li, S. Jain, M. S. Shell, J. V. Israelachvili, S. Han, Proc. Natl. Acad. Sci. U.S.A., 115 (12) (2018) 2890-2895.
DOI:10.1073/pnas.1722263115
Highlighted in the UC Santa Barbara Current:
http://www.news.ucsb.edu/2018/018793/glass-matters

Perspective of Overhauser Dynamic Nuclear Polarization for the Study of Soft Materials
R. Barnes, S. Han, J. Biller, Curr. Opin. Colloid Interface Sci., 33(2018), 72-85.
DOI:10.1016/j.cocis.2018.02.007

2017 Journal Articles

Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium
R. Barnes, S. Sun, Y. Fichou, F.W. Dahlquist, M. Heyden, S. Han, J. Am. Chem. Soc., 139 (49) (2017) 17890-17901.
DOI: 10.1021/jacs.7b08606
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/49

Simple peptide coacervates adapted for rapid pressure-sensitive wet adhesion
I. Kaminker, W. Wei, A.M. Schrader, Y. Talmon, M.T. Valentine, J.N. Israelachvili, J.H. Waite, S. Han, Soft Matter., 13 (48) (2017) 9122-9131.
DOI: 10.1039/C7SM01915G

Universal Dynamics of Molecular Reorientation in Hybrid Lead Iodide Perovskites
D.H Fabini, T.A. Siaw, C.C. Stoumpos, G. Laurita, D. Olds, K. Page, J.G. Hu, M.G. Kanatzidis, S. Han, R. Seshadri, J. Am. Chem. Soc., 139 (46) (2017) 16875-16884.
DOI: 10.1021/jacs.7b09536
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/46

Conformation-based assay of tau protein aggregation
Y. Fichou, N.A. Eschmann, T.J. Keller, S. Han, Methods Cell Biol., 141 (2017) 89-112.
DOI: 10.1016/bs.mcb.2017.06.008

Proton-based structural analysis of heptahelical transmembrane protein in lipid bilayers
D. Lalli, M.N. Idso, L.B. Andreas, S. Hussain, N. Baxter, S. Han, B. Chmelka, G. Pintacuda, J. Am. Chem. Soc., 139 (37) (2017) 13006-13012.
DOI: 10.1021/jacs.7b02969. PMID: 28724288. PMCID: PMC5741281.
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/37

Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure
J.H. Ortony, B. Qiao, C.J. Newcomb, T.J. Keller, L.C. Palmer, E. Deiss-Yehiely, M.O. Cruz S. Han, S.I. Stupp, J. Am. Chem. Soc., 139 (26) (2017) 8915–8921
DOI: 10.1021/jacs.7b02969
Highlighted in Nature Chemistry News and Views: http://doi.org/10.1038/nchem.2870

RNA Stores Tau Reversibly in Complex Coacervates
X. Zhang, N.E. Eschmann, Y. Lin, H. Zhou, J. Rauch, I. Hernandez, E. Guzman, K.S. Kosik, S. Han, PLOS Biol., 15 (7) (2017) e2002183.
DOI: 10.1371/journal.pbio.2002183. PMID: 28683104. PMCID: PMC5500003
Also published in bioRxiv:
DOI: 10.1016/10.1101/111245
Highlighted in:
http://www.medicalnewstoday.com/releases/318265.php
http://www.news.ucsb.edu/2017/018072/biophysical-smoking-gun

Arbitrary waveform modulated pulse EPR at 200 GHz
I. Kaminker, R. Barnes, S. Han, J. Magn. Reson., 279 (2017) 81-90
DOI: 10.1016/j.jmr.2017.04.016. PMID: 28482216. PMCID: PMC5519772

Signature of an aggregation-prone conformation of tau
N.A. Eschmann, E.R. Georgieva, P. Ganguly, P.P. Borbat, M.D. Rappaport, Y. Akdogan, J.H. Freed, J.E. Shea, S. Han, Sci. Rep., 7 (2017) 1-10
DOI:10.1038/srep44739. PMID: 28303942. PMCID: PMC5356194

Gd3+-Gd3+ distances exceeding 3 nm determined by very high frequency continuous wave electron paramagnetic resonance
J.A. Clayton, M. Qi, A. Godt, D. Goldfarb, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 19 (7) (2017)5127-5136
DOI:10.1039/C6CP07119H. PMID: 28139788. PMCID: PMC5394103

Effect of electron spectral diffusion on static dynamic nuclear polarization at 7 Tesla
A. Leavesley, D. Shimon, T. Siaw, A. Feintuch, D. Goldfarb, S. Vega, I. Kaminker, S. Han, Phys. Chem. Chem. Phys., 19 (5)(2017) 3596-3605.
DOI:10.1039/C6CP06893F. PMID: 28094364