Publications

Publications

2020 Journal Articles

Balancing Dipolar and Exchange coupling in Biradicals to Maximize Cross Effect Dynamic Nuclear Polarization
A. Equbal, K. Tagami, and S. Han Phys. Chem. Chem. Phys. (2020)
https://doi.org/10.1039/D0CP02051F

Crossover from a Solid Effect to Thermal Mixing 1H Dynamic Nuclear Polarization with Trityl-OX063
A. Equbal, Y. Li, T. Tabassum, and S. Han J. Phys. Chem. Lett. (2020)
https://pubs.acs.org/doi/10.1021/acs.jpclett.0c00830

Tuning molecular adsorption in SBA-15-type periodic mesoporous organosilicas by systematic variation of their surface polarity
H. Moon, S. Han, and S. Scott. Chem. Sci. (2020)
https://doi.org/10.1039/D0SC00168F

Mechanisms of heparin-induced tau aggregation revealed by single nanopore
N. Giamblanco, Y. Fichou, J.-M. Janot, E. Balanzat, S. Han, and S. Balme. ACS Sens. (2020)
https://pubs.acs.org/doi/abs/10.1021/acssensors.0c00193

Water Structure and Properties at Hydrophilic and Hydrophobic Surfaces
J. Monroe, M. Barry, A. DeStefano, P. A. Gorturk, S. Jiao, D. Robinson-Brown, T. Webber, E. J. Crumlin, S. Han, and S. Shell. Annu. Rev. Chem. Biomol. Eng. (2020)
https://doi.org/10.1146/annurev-chembioeng-120919-114657

Electrostatic Environment of Proteorhodopsin Affects the pKa of Its Buried Primary Proton Acceptor
C.-T. Han, J. Song, T. Chan, C. Pruett, and S. Han. Biophys. J. (2020)
https://doi.org/10.1016/j.bpj.2020.02.027

Electrostatically driven complex coacervation and amyloid aggregation of tau are independent processes with overlapping conditions.
Y. Lin, Y. Fichou, Z. Zeng, N. Y. Hu, and S. Han. ACS Chem. Neurosci. (2020)
https://doi.org/10.1021/acschemneuro.9b00627
Also published in BioRxiv: 
https://doi.org/10.1101/702126

2019 Journal Articles

Tracing Dynamic Nuclear Polarization Pathways Using Transition Metal - Nuclear Spin Rulers
S. K. Jain, C.-J. Yu, B. Wilson, T. Tabassum, D. E. Freedman, and S. Han. ChemRxiv (2019)
https://doi.org/10.26434/chemrxiv.11340752.v1

Tau-cofactor complexes as building blocks of tau fibrils
Y. Fichou, Z. R. Oberholtzer, H. Ngo, C.-Y. Cheng, T. J. Keller, N. A. Eschmann, and S. Han. Front. Neurosci. (2019)
https://doi.org/10.3389/fnins.2019.01339

Pulse Shaped Dynamic Nuclear Polarization Under Magic Angle Spinning
A. Equbal, K. Tagami, and S. Han. J. Phys. Chem. Lett., 10 (2019), 7781-7788.
https://doi.org/10.1021/acs.jpclett.9b03070
Also published in ChemRxiv: 
https://doi.org/10.26434/chemrxiv.9788471.v1
Live Video Presentation on the topic can be found here.

Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms
M. Lin, N. K. Pandey, R. Barnes, S. Han, and R. Langen. Structure (2019)
https://doi.org/10.1016/j.str.2019.08.003

Electron Spin Density Matching for Cross-Effect Dynamic Nuclear Polarization
Y. Li, A. Equbal, K. Tagami, and S. Han. Chem. Commun., 55 (2019), 7591-7594.
https://doi.org/10.1039/C9CC03499D

Protein shapes at the core of chronic traumatic encephalopathy
Y. Fichou and S. Han. Nature Struct. Mol. Biol., 26 (2019), 336-338.
https://doi.org/10.1038/s41594-019-0221-2

Biradical rotamer states tune electron J coupling and MAS dynamic nuclear polarization enhancement
K. Tagami, A. Equbal, I. Kaminker, B. Kirtman, and S. Han Solid State Nucl. Mag. Res., 101 (2019), 12-20.
https://doi.org//10.1016/j.ssnmr.2019.04.002

Proteorhodopsin Function is Primarily Mediated by Oligomerization in Different Micellar Surfactant Solutions
M. N. Idso, N. R. Baxter, S. Narayanan, E. Chang, J. M. Fisher, B. F. Chmelka, and S. Han J. Phys. Chem. B, 123 (19) (2019), 4180-4192.
https://doi.org/10.1021/acs.jpcb.9b00922

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
Y. Lin, J. McCarty, J. N. Rauch, K. T. Delaney, K. S. Kosik, G. H. Fredrickson, J.-E. Shea, S. Han. eLife, 8 (2019), e42571
https://doi.org/10.7554/eLife.42571

Anomalous solute diffusivity in ionic liquids: Label-free visualization and physical origins
A. V. Bayles, C. S. Valentine, T. Überrück, S. P. O. Danielsen, S. Han, M. E. Helgeson, T. M. Squires. Phys. Rev. X, 9 (2018), 011048.
https://doi.org/10.1103/PhysRevX.9.011048

Cross-Effect Dynamic Nuclear Polarization Explained: Polarization, Depolarization, and Oversaturation
A. Equbal, A. Leavesley, S. K. Jain, S. Han. J. Phys. Chem. Lett., 10 (2019), 548-558.
https://doi.org/10.1021/acs.jpclett.8b02834
Content of this publication inspired design of cover art of entailing journal issue.
https://pubs.acs.org/toc/jpclcd/10/3

2019 Book Chapter

Methods in Enzymology: Biological NMR Part B
Vol. 615, Elsevier Inc. (2019), 131-175.

Chapter Five - Overhauser Dynamic Nuclear Polarization for the Study of Hydration Dynamics, Explained
J. M. Franck and S. Han
https://doi.org/10.1016/bs.mie.2018.09.024

2018 Journal Articles

Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities
A. Leavesley, I. Kaminker, S. Han. eMagRes, 7 (2018), 133-154.
https://doi.org/10.1002/9780470034590.emrstm1564
Included as part of the "Handbook of High Frequency Dynamic Nuclear Polarization NMR" series.

Cofactors are essential constituents of stable and seeding-active tau fibrils
Y. Fichou, Y. Lin, J. N. Rauch, M. Vigers, Z. Zeng, M. Srivastava, T. J. Keller, J. H. Freed, K. S. Kosik, S. Han. Proc. Nat. Acad. Sci., 115 (52) (2018), 13234-13239.
https://doi.org/10.1073/pnas.1810058115
Highlighted in the UC Santa Barbara Current:
http://www.news.ucsb.edu/2018/019293/three-player-game

Effect of nitroxide spin probes on the transport properties of Nafion membranes
T. Überrück, O. Neudert, K.-D. Kreuer, B. Blümich, J. Granwehr, S. Stapf, S. Han. Phys. Chem. Chem. Phys., 20 (2018), 26660-26674.
https://doi.org/10.1039/C8CP04607G

Maximizing NMR signal per unit time by facilitating the e-e-n cross effect DNP rate
A. Leavesley, S. Jain, I. Kaminker, H. Zhang, S. Rajca, A. Rajca, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 27646-27654.
https://doi.org/10.1039/C8CP04909B. PMID: 30375593. PMCID: PMC6370975. NIHMSID: NIHMS995519.
Selected 2018 PCCP Hot Article

Tuning nuclear depolarization under MAS by electron T1e
A. Lund, A. Equibal, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 23976-23987.
https://doi.org/10.1039/C8CP04167A. PMID: 30211922. PMCID: PMC6208319. NIHMSID: NIHMS989193
Selected 2018 PCCP Hot Article

Heterogeneity of network structure and water dynamics in ?-carrageenan gels probed by nanoparticle diffusometry
D. de Kort, E. Schuster, F. Hoeben, R. Barnes, M. Emondts, H. Janssen, N. Lorén, S. Han, H. van As, J. van Duynhoven. Langmuir, 34 (37) (2018), 11110-11120.
https://doi.org/10.1021/acs.langmuir.8b01052

Multi-step phase-cycling in a free-electron laser-powered pulsed electron paramagnetic resonance spectrometer
C. B. Wilson, S. Aronson, J. A. Clayton, S. J. Glaser, S. Han, M. S. Sherwin. Phys. Chem. Chem. Phys., 20 (2018), 18097-18109.
https://doi.org/10.1039/C8CP01876F

Amplification of Dynamic Nuclear Polarization at 200 GHz by Arbitrary Pulse Shaping of the Electron Spin Saturation Profile
I. Kaminker, S. Han. J. Phys. Chem. Lett., 9 (11) (2018), 3110-3115.
https://doi.org/10.1021/acs.jpclett.8b01413

Tuning conformation and properties of peptidomimetic backbones through dual N/C?-substitution
R. Kaminker, I. Kaminker, W. R. Gutekunst, Y. Luo, S. Lee, J. Niu, S. Han, C. J. Hawker. Chem. Comm., 54 (41) (2018), 5237-5240.
https://doi.org/10.1039/C8CC01356J

Truncated Cross Effect Dynamic Nuclear Polarization: An Overhauser Effect Doppelgänger
A. Equbal, Y. Li, A. Leavesley, S. Huang, S. Rajca, A. Rajca, S. Han, J. Phys. Chem. Lett., 9 (9) (2018), 2175-2180.
https://doi.org/10.1021/acs.jpclett.8b00751

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer’s disease filaments
Y. Fichou, M. Vigers, A. K. Goring, N. A. Eschmann, S. Han, Chem. Commun., 54 (36) (2018), 4573-4576.
PMID: 29664486
https://doi.org/10.1039/C8CC01355Aa

Quantitative analysis of zero-field splitting parameter distributions in Gd(III) complexes
J. A. Clayton, K. Keller, M. Qi, J. Wegner, V. Koch, H. Hintz, A. Godt, S. Han, G. Jeschke, M. S. Sherwin, M. Yulikov, Phys. Chem. Chem. Phys., 20 (15) (2018), 10470-10492.
https://doi.org/10.1039/c7cp08507a. PMID: 29617015. PMCID: PMC6026474.

Functionally Active Membrane Proteins Incorporated in Mesostructured Silica Films
J. P. Jahnke, M. N. Idso, S. Hussain, M. J. N. Junk, J. M. Fisher, D. D. Phan, S. Han, B. F. Chmelka, J. Am. Chem. Soc., 140 (11) (2018), 3892-3906.
https://doi.org/10.1021/jacs.7b06863 PMID: 29533066.

Effect of Water/Glycerol Polymorphism on Dynamic Nuclear Polarization
A. Leavesley, C. B. Wilson, M. Sherwin, S. Han, Phys. Chem. Chem. Phys, 20 (15) (2018), 9897-9903.
https://doi.org/10.1039/C8CP00358K

Reversal of Paramagnetic Effects by Electron Spin Saturation
S. K. Jain, T. A. Siaw, A. Equbal, C. B. Wilson, I. Kaminker, S. Han, J. Phys. Chem. C, 122 (10) (2018), 5578-5589.
https://doi.org/10.1021/acs.jpcc.8b00312

Surface Chemical Heterogeneity Modulates Silica Surface Hydration
A. M. Schrader, J. I. Monroe, R. Sheil, H. A. Dobbs, T. J. Keller, Y. Li, S. Jain, M. S. Shell, J. V. Israelachvili, S. Han, Proc. Natl. Acad. Sci. U.S.A., 115 (12) (2018) 2890-2895.
https://doi.org/10.1073/pnas.1722263115
Highlighted in the UC Santa Barbara Current:
http://www.news.ucsb.edu/2018/018793/glass-matters

Perspective of Overhauser Dynamic Nuclear Polarization for the Study of Soft Materials
R. Barnes, S. Han, J. Biller, Curr. Opin. Colloid Interface Sci., 33(2018), 72-85.
https://doi.org/10.1016/j.cocis.2018.02.007

2017 Journal Articles

Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium
R. Barnes, S. Sun, Y. Fichou, F.W. Dahlquist, M. Heyden, S. Han, J. Am. Chem. Soc., 139 (49) (2017) 17890-17901.
https://doi.org/10.1021/jacs.7b08606
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/49

Simple peptide coacervates adapted for rapid pressure-sensitive wet adhesion
I. Kaminker, W. Wei, A.M. Schrader, Y. Talmon, M.T. Valentine, J.N. Israelachvili, J.H. Waite, S. Han, Soft Matter., 13 (48) (2017) 9122-9131.
https://doi.org/10.1039/C7SM01915G

Universal Dynamics of Molecular Reorientation in Hybrid Lead Iodide Perovskites
D.H Fabini, T.A. Siaw, C.C. Stoumpos, G. Laurita, D. Olds, K. Page, J.G. Hu, M.G. Kanatzidis, S. Han, R. Seshadri, J. Am. Chem. Soc., 139 (46) (2017) 16875-16884.
https://doi.org/10.1021/jacs.7b09536
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/46

Conformation-based assay of tau protein aggregation
Y. Fichou, N.A. Eschmann, T.J. Keller, S. Han, Methods Cell Biol., 141 (2017) 89-112.
https://doi.org/10.1016/bs.mcb.2017.06.008

Proton-based structural analysis of heptahelical transmembrane protein in lipid bilayers
D. Lalli, M.N. Idso, L.B. Andreas, S. Hussain, N. Baxter, S. Han, B. Chmelka, G. Pintacuda, J. Am. Chem. Soc., 139 (37) (2017) 13006-13012.
https://doi.org/10.1021/jacs.7b02969. PMID: 28724288. PMCID: PMC5741281.
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/37

Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure
J.H. Ortony, B. Qiao, C.J. Newcomb, T.J. Keller, L.C. Palmer, E. Deiss-Yehiely, M.O. Cruz S. Han, S.I. Stupp, J. Am. Chem. Soc., 139 (26) (2017) 8915–8921
https://doi.org/10.1021/jacs.7b02969
Highlighted in Nature Chemistry News and Views: http://doi.org/10.1038/nchem.2870

RNA Stores Tau Reversibly in Complex Coacervates
X. Zhang, N.E. Eschmann, Y. Lin, H. Zhou, J. Rauch, I. Hernandez, E. Guzman, K.S. Kosik, S. Han, PLOS Biol., 15 (7) (2017) e2002183.
https://doi.org/10.1371/journal.pbio.2002183. PMID: 28683104. PMCID: PMC5500003
Also published in bioRxiv:
https://doi.org/10.1016/10.1101/111245
Highlighted in:
http://www.medicalnewstoday.com/releases/318265.php
http://www.news.ucsb.edu/2017/018072/biophysical-smoking-gun

Arbitrary waveform modulated pulse EPR at 200 GHz
I. Kaminker, R. Barnes, S. Han, J. Magn. Reson., 279 (2017) 81-90
https://doi.org/10.1016/j.jmr.2017.04.016. PMID: 28482216. PMCID: PMC5519772

Signature of an aggregation-prone conformation of tau
N.A. Eschmann, E.R. Georgieva, P. Ganguly, P.P. Borbat, M.D. Rappaport, Y. Akdogan, J.H. Freed, J.E. Shea, S. Han, Sci. Rep., 7 (2017) 1-10
https://doi.org/10.1038/srep44739. PMID: 28303942. PMCID: PMC5356194

Gd3+-Gd3+ distances exceeding 3 nm determined by very high frequency continuous wave electron paramagnetic resonance
J.A. Clayton, M. Qi, A. Godt, D. Goldfarb, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 19 (7) (2017) 5127-5136
https://doi.org/10.1039/C6CP07119H. PMID: 28139788. PMCID: PMC5394103

Effect of electron spectral diffusion on static dynamic nuclear polarization at 7 Tesla
A. Leavesley, D. Shimon, T. Siaw, A. Feintuch, D. Goldfarb, S. Vega, I. Kaminker, S. Han, Phys. Chem. Chem. Phys., 19 (5) (2017) 3596-3605.
https://doi.org/10.1039/C6CP06893F. PMID: 28094364

2016 Journal Articles

Hydration dynamics of a peripheral membrane protein
O. Fisette, C. Paslack, R. Barnes, J.M. Isas, R. Langen, M. Heyden, S. Han, L.V. Schafer, J. Am Chem. Soc., 138 (2016) 11526-11535
https://doi.org/10.1021/jacs.6b07005 PMID: 27548572; PMCID: PMC5519773.

Adenosine A2a receptors form distinct oligomers in protein detergent complexes
N.S. Schonenbach, M.D. Rieth, S. Han, M.A. O'Malley, FEBS Lett., 590 (2016) 3295–3306
https://doi.org/10.1002/1873-3468.12367 PMID: 27543907; PMCID: PMC5039092.

Contrasting Effects of Glycerol and DMSO on Lipid Membrane Surface Hydration Dynamics and Forces
A. Schrader, C. Cheng, J. Israelachvili, S. Han, J. Chem. Phys., 145 (2016) 041101
https://doi.org/10.1063/1.4959904 PMID: 27475340; PMCID: PMC4967073.

Molecular and structural basis of low interfacial energy of complex coacervates in water
Y. Jho, H. Yoo, Y. Lin, S. Han, D. Hwang, Adv. Colloid Interface Sci., 239 (2017) 61–73
https://doi.org/10.1016/j.cis.2016.07.003. PMID: 27499328.

Biocontinuous Fluid Structure with Low Cohesive Energy: Molecular Basis for Exceptionally Low Interfacial Tension of Complex Coacervate Fluids
K. Huang, H. Yoo, Y. Jho, S. Han, D. Hwang, ACS Nano, 10 (2016) 5051-5062
https://doi.org/10.1021/acsnano.5b07787

Stability of protein-specific hydration shell on crowding
K. Huang, C.N. Kingsley, R. Sheil, C. Cheng, J.B. Bierma, K.W. Roskamp, D. Khago, R.W. Martin, S. Han, J. Am. Chem. Soc., 138 (16) (2016) 5392–5402
https://doi.org/10.1021/jacs.6b01989 PMID: 27052457.

A versatile and modular quasi optics-based 200 GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument
T.A. Siaw, A. Leavesley, A. Lund, I. Kaminker, S. Han, J. Magn. Reson., 264 (2016) 131-153
https://doi.org/10.1016/j.jmr.2015.12.012 PMCID: PMC4770585.

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau
A. Pavlova, C. Cheng, M. Kinnebrew, J. Lew, F. Dahlquist, S. Han, Proc. Natl. Acad. Sci., 113 (2) (2016) E127-E136
https://doi.org/10.1073/pnas.1504415113 PMCID: PMC4720316

2015 Journal Articles

Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?
P. Stals, C. Cheng, L. Beek, A. Wauters, A. Palmans, S. Han, E. Meijer, Chem. Sci., 7 (2015) 2011-2015
https://doi.org/10.1039/C5SC02319J

Tau Aggregation Propensity Engrained in Its Solution State
N. Eschmann, T. Do, N. LaPointe, J. Shea, S. Feinstein, M. Bowers, S. Han, J. Phys. Chem., 119 (45) (2015) 14421–14432
https://doi.org/10.1021/acs.jpcb.5b08092 PMID: 26484390; PMCID: PMC4645975

Mussel Coating Protein-Derived Complex Coacervates Mitigate Frictional Surface Damage
D. Miller, S. Das, K. Huang, S. Han, J. Israelachvili, J. Waite, ACS Biomater. Sci. Eng., 1 (11) (2015) 1121–1128
https://doi.org/10.1021/acsbiomaterials.5b00252 PMID: 26618194; PMCID: PMC4642218
ACS Editors' Choice Paper

Direct Dynamic Nuclear Polarization Targeting Catalytically Active 27Al Sites
A. Lund, M. Hsieh, T. Siaw, S. Han, Phys. Chem. Chem. Phys., 17 (2015) 25449-25454
https://doi.org/10.1039/C5CP03396A PMID: 26365719

Anomalously rapid hydration water diffusion dynamics near DNA surfaces
J. Franck, Y. Ding, K. Stone, P. Qin, S. Han, J. Am. Chem. Soc., 137 (37) (2015) 12013-12023
https://doi.org/ 10.1021/jacs.5b05813 PMID: 26256693; PMCID: PMC4656248

Correlating steric-hydration forces with water dynamics through surface force and diffusion NMR measurements in a lipid-DMSO-H2O system
A. Schrader, S. Donaldson, J. Song, C. Cheng, D. Lee, S. Han, J. Israelachvili, Proc. Natl. Acad. Sci., 112 (34) (2015) 10708–10713
https://doi.org/10.1073/pnas.1512325112 PMID: 26261313; PMCID: PMC4553805

Active Cancellation - A Means to Zero Dead-Time Pulse EPR
J. Franck, R. Barnes, T. Keller, T. Kaufmann, S. Han, J. Magn. Reson., 261 (2015) 199-204
https://doi.org/10.1016/j.jmr.2015.07.005 PMID: 26507308; PMCID: PMC4688155

DMSO induces dehydration near lipid membrane surfaces
C. Cheng, J. Song, J. Pas, L. Meijer, S. Han, Biophys. J., 109 (2) (2015) 330-339
https://doi.org/10.1016/j.bpj.2015.06.011 PMID: 26200868; PMCID: PMC4621616

Ion specific effects: decoupling ion-ion and ion-water interactions
J. Song, M. Kim, T. Kang, S. Han, Phys. Chem. Chem. Phys., 17 (2015) 8306-8322
https://doi.org/10.1039/C4CP05992A PMID: 25761273; PMCID: PMC4656249

Functional Consequences of the Oligomeric Assembly of Proteorhodopsin
S. Hussain, M. Kinnebrew, N. Schonenbach, E. Aye, S. Han, J. Molec. Biol., 427 (6B) (2015) 1278-1290
https://doi.org/10.1016/j.jmb.2015.01.004 PMID: 25597999; PMCID: PMC4374980

Nanometer-Scale Water and Proton Diffusion Heterogeneities across Water Channels in Polymer Electrolyte Membranes
J. Song, O. H. Han,  S. Han, Angew. Chem., 54 (12) (2015) 3615-3620
https://doi.org/10.1002/anie.201408318 PMID: 25630609; PMCID: PMC4450673

2015 Book Chapters

Methods in Enzymology: Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions - Part B
Edited by: P. Z. Qin, K. Warncke

Vol. 564, Elsevier Inc. (2015)
Overhauser Dynamic Nuclear Polarization Studies on Local Water Dynamics
I. Kaminker, R. Barnes, and S. Han
https://doi.org/10.1016/bs.mie.2015.06.040 PMID: 26477261

Protein NMR - Modern Techniques and Biomedical Applications
Edited by: Lawrence Berliner

Vol. 32, Springer (2015) 43-74
Mapping Out Protein Hydration Dynamics by Overhauser Dynamic Nuclear Polarization
C. Cheng, J. Song, J. Franck, S. Han
https://doi.org/10.1007/978-1-4899-7621-5_2

2014 Journal Articles

Local water diffusivity as a molecular probe of surface hydrophilicity 
J. Song, B. Allison, S. Han, MRS Bull., 39 (12) (2014) 1082-1088
https://doi.org/10.1557/mrs.2014.254

Cholesterol Enhances Surface Water Diffusion of Phospholipid Bilayers
C. Y. Cheng, L. Olijve, R. Kausik, S. Han, J. Chem. Phys., 141 (22D513) (2014)
https://doi.org/10.1063/1.4897539 PMID: 25494784; PMCID: PMC4201661

Determining the oligomeric structure of proteorhodopsin by Gd3+-based pulsed dipolar spectroscopy of multiple distances
D.T. Edwards, T. Huber, S. Hussain, K.M. Stone, M. Kinnebrew, I. Kaminker, E. Matalon, M.S. Sherwin, D. Goldfarb, S. Han, Structure, 22 (11) (2014) 1677-1686
https://doi.org/10.1016/j.str.2014.09.008 PMID: 25438671.

Intrinsic Surface-Drying Properties of Bioadhesive Proteins
Y. Akdogan, W. Wei, K. Huang, Y. Kageyama, E. W. Danner, D. R. Miller, N. R. Martinez Rodriguez, J. H. Waite, S. Han, Angew. Chem., 126 (42) (2014) 11435-11438
https://doi.org/10.1002/ange.201406858 PMID: 25168789; PMCID: PMC4198389
Featured in Nature Materials | Research Highlights

Role of Electron Spin Dynamics on Solid-State Dynamic Nuclear Polarization Performance
T. Siaw, M. Fehr, A. Lund, A. Latimer, S. Walker D. Edwards, S. Han, Phys. Chem. Chem. Phys., 16 (2014) 18694-18706.
https://doi.org/10.1039/C4CP02013H PMID: 24968276.

Probing water density and dynamics in the chaperonin GroEL cavity
J. Franck, M. Sokolovski, N. Kessler, E. Matalon, M. Gordon-Grossman, S. Han, D. Goldfarb, A. Horovitz, J. Am. Chem. Soc., 136 (26) (2014) 9396-9403
https://doi.org/10.1021/ja503501x PMID: 24888581; PMCID: PMC4091268

Specific Ions Modulate Diffusion Dynamics of Hydration Water on Lipid Membrane Surfaces
J. Song, J. Franck, P. Pincus, M.W. Kim, S. Han, J. Am. Chem. Soc., 136 (6) (2014) 2642-2649
https://doi.org/10.1021/ja4121692 PMID: 24456096; PMCID: PMC3985948

2013 Journal Articles

Fluidity and Water in Nanoscale Domains Define Coacervate Hydrogels
J.H. Ortony, S.H. Choi, J.M. Spruell, J.N. Hunt, N.A. Lynd, D.V. Krogstad, V.S. Urban, C.J. Hawker, E.J. Kramer, S. Han, Chemical Sciences 5 (2013) 58-67
https://doi.org/10.1039/C3SC52368C

Hydration Dynamics as an Intrinsic Ruler for Refining Protein Structure at Lipid Membrane Interfaces
C.Y. Cheng, J. Varkey, M.R. Ambroso, R. Langen, S. Han, Proc. Natl. Acad. Sci. 110 (42) (2013) 16838–16843
https://doi.org/10.1073/pnas.1307678110 PMID: 24082088; PMCID: PMC3800990

DAC-board based X-band EPR Spectrometer with Arbitrary Waveform Control (w/Audio Slide Presentation)
T. Kaufmann, T.J. Keller, J.M. Franck, R.P. Barnes, S.J. Glaser, J.M. Martinis, S. Han, J. Magn. Reson. 235 (2013) 95-108
https://doi.org/10.1016/j.jmr.2013.07.015 PMID: 23999530; PMCID: PMC3863685

Quantitative cw Overhauser Dynamic Nuclear Polarization for the Analysis of Local Water Dynamics
J. M. Franck, A. Pavlova, J.A. Scott, S. Han, Prog. Nucl. Magn. Reson. 74 (2013) 33-56
https://doi.org/10.1016/j.pnmrs.2013.06.001 PMID: 24083461; PMCID: PMC3798041

Temperature Dependence of High Field 13C Dynamic Nuclear Polarization Processes below 35 Kelvin
S.A. Walker, D.T. Edwards, T. Siaw, B.D. Armstrong, S. Han, Phys. Chem. Chem. Phys. 15 (36) (2013) 15106-15120
https://doi.org/10.1039/C3CP51628H PMID: 23925724.

Extending the Distance Range Accessed with Continuous Wave EPR with Gd3+ Spin Probes at High Magnetic Fields
D.T. Edwards, Z. Ma, T.J. Meade, D. Goldfarb, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 15 (2013) 11313-11326
https://doi.org/10.1039/C3CP43787F PMID: 23732863; PMCID: PMC4142211

Overhauser Dynamic Nuclear Polarization-Enhanced NMR Relaxometry
J.M. Franck, R. Kausik, S. Han, Microporous and Mesoporous Materials, 178 (2013) 113-118
https://doi.org/10.1016/j.micromeso.2013.04.019 PMID: 23837010; PMCID: PMC3702190

Asymmetric Collapse in Biomimetic Complex Coacervates Revealed by Local Polymer and Water Dynamics
J.H. Ortony, D.S. Hwang, J.M. Franck, J.H. Waite, S. Han, Biomacromolecules, 14(5) (2013) 1395-1402
https://doi.org/10.1021/bm4000579 PMID: 23540713; PMCID: PMC4090114

Phase Cycling with a 240 GHz Free Electron Laser-powered Electron Paramagnetic Resonance Spectrometer
D.T. Edwards, Y. Zhang, S.J. Glaser, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 15 (2013) 5707-5719
https://doi.org/10.1039/C3CP44492A PMID: 23474874.

Nonlinear Scaling of Surface Water Diffusion with Bulk Water Viscosity of Crowded Solutions
J.M. Franck, J.A. Scott, S. Han, J. Am. Chem. Soc., 135(11) (2013) 4175-4178
https://doi.org/10.1021/ja3112912 PMID: 23347324; PMCID: PMC3785640.

Structural Insight into Proteorhodopsin Oligomers
K. M. Stone, J. Voska, M. Kinnebrew, A. Pavlova, M. J. N. Junk, S. Han, Biophys. J., 104(2) (2013) 472-481
https://doi.org/10.1016/j.bpj.2012.11.3831 PMID: 23442869; PMCID: PMC3552253

Dynamic Nuclear Polarization Methods in Solids and Solutions to Explore Membrane Proteins and Membrane Systems
C.Y. Cheng and S. Han, Annu. Rev. Phys. Chem., 64 (2013) 507-532
https://doi.org/10.1146/annurev-physchem-040412-110028 PMID: 23331309.

Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics
S. Hussain, J. M. Franck, S. Han, Angew. Chem. Int. Ed., 52(7) (2013) 1953-1958
https://doi.org/10.1002/anie.201206147 PMID: 23307344

2013 Journal Articles

Annual Review of Physical Chemistry
Vol. 64, Annual Reviews (2013)
Dynamic Nuclear Polarization Methods in Solids and Solutions to Explore Membrane Proteins and Membrane Systems
C. Cheng and S. Han
https://doi.org/10.1146/annurev-physchem-040412-110028 PMID: 23331309

2012 Journal Articles

Quantitative Analysis of Molecular Transport across Liposomal Bilayer by J-mediated 13C Dynamic Nuclear Polarization
C.Y. Cheng, J.G.M.O. Goor, S. Han, Anal. Chem., 84(21) (2012) 3936-3940
https://doi.org/10.1021/ac301932h PMID: 23072518; PMC4656247.

Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: The Role of Hydration Dynamics Revealed by Dynamic Nuclear Polarization
C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, Biomacromolecules, 13(9) (2012) 2624-2633
https://doi.org/10.1021/bm300848c PMID: 22808941.

Distance measurements across randomly distributed nitroxide probes from the temperature dependence of the electron spin phase memory time at 240 GHz
D.T. Edwards, S. Takahashi, M. S. Sherwin, S. Han, J. Magn. Reson., 223 (2012) 198-206
https://doi.org/10.1016/j.jmr.2012.07.004 PMID: 22975249.

Inductively coupled NMR probe for versatile dynamic nuclear polarization operation at 7 Tesla: observation of 61 ± 2% 1H polarization at 4 K
T. Siaw, S. A. Walker, B. D. Armstrong, S. Han, J. Magn. Reson., 221 (2012) 5-10
https://doi.org/10.1016/j.jmr.2012.05.017 PMID: 22743536.

Hyperpolarized Water as an MRI Contrast Agent
M. D. Lingwood, T. Siaw, N. Sailasuta, O. A. Abulseoud, H. R. Chan, B. D. Ross, P. Bhattacharya, S. Han, , Radiology, 265 (3) (2012) 418-425
https://doi.org/ 10.1148/radiol.1211180 PMID: 22996746; PMCID: PMC3480810.

Pulsed electron paramagnetic resonance spectroscopy powered by a free-electron laser
S. Takahashi, L.-C. Brunel, D. T. Edwards, J. van Tol, G. Ramian, S. Han, M. S. Sherwin, Nature 489 (74160) (2012)409-13
https://doi.org/10.1038/nature11437 PMID: 22996555.

Overhauser dynamic nuclear polarization amplification of NMR flow imaging
M. D. Lingwood, A. J. Sederman, M. D. Mantle, L. F. Gladden, S. Han, J. Magn. Reson. 216 (2012) 94–100
https://doi.org/10.1016/j.jmr.2012.01.007

An ultrasensitive tool exploiting hydration dynamics to decipher weak lipid membrane–polymer interactions
C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, J. Magn. Reson. 215 (2012) 115-119
https://doi.org/10.1016/j.jmr.2011.12.004 PMID: 22230738.

2011 Journal Articles

Site-Specific Hydration Dynamics in the Nonpolar Core of a Molten Globule by Dynamic Nuclear Polarization of Water
B.D. Armstrong, J. Choi, C. Lopez, D. A. Wesener, W. Hubbell, S. Cavagnero, S. Han, J. Am. Chem. Soc.133 (2011) 5987–5995
https://doi.org/10.1021/ja111515s PMID: 21443207; PMCID: PMC3095581

Dynamics and State of Lipid Bilayer-internal Water Unraveled with Solution State 1H Dynamic Nuclear Polarization
R. Kausik, S. Han, Phys. Chem. Chem. Phys. (2011) 13, 7732-7746
https://doi.org/10.1039/c0cp02512g PMID: 21423982.

Probing the Hydration Water Diffusion of Macromolecular Surfaces and Interfaces
J. H. Ortony, C.-Y. Cheng, R. Kausik, A. Pavlova, J. Hunt, S. Han, New J. Phys.13 (2011) 015006 (15pp)
https://doi.org/10.1088/1367-2630/13/1/015006

2011 Book Chapters

Annual Reports on NMR Spectroscopy
Edited by: Graham A. Webb

Vol. 73, Elsevier Academic Press (2011)
Solution State Dynamics Nuclear Polarization 
M. D. Lingwood, S. Han. (Pages 83-126)
https://doi.org/10.1016/B978-0-08-097074-5.00003-7 PMID: 12137529

2007–2010 Journal Articles

A 200 GHz Dynamic Nuclear Polarization Spectrometer
B.D. Armstrong, D.T. Edwards, R.J. Wylde, S.A. Walker, S. Han, Phys. Chem. Chem. Phys., 12 (2010) 5920-5926
https://doi.org/10.1039/c002290j PMID: 20461268.

Continuous Flow Overhauser Dynamic Nuclear Polarization of Water in the Fringe Field of a Clinical Magnetic Resonance Imaging System for Authentic Image Contrast
M. D. Lingwood, T. A. Siaw, N. Sailasuta, B. D. Ross, P. Bhattacharya and S. Han, J. Magn. Reson. 205 (2) (2010) 247-254
https://doi.org/10.1016/j.jmr.2010.05.008 PMID: 20541445; PMCID: PMC4724375.

Heisenberg Spin Exchange Effects of Nitroxide Radicals on Overhauser Dynamic Nuclear Polarization in the Low Field Limit at 1.5 mT
M.D. Lingwood, I.A. Ivanov, A.R. Cote, S. Han, J. Magn. Reson. 204 (1) (2010) 56-63
https://doi.org/10.1016/j.jmr.2010.01.015 PMID: 20188611.

L-band Overhauser dynamic nuclear polarization
S. Garcia, J.H. Walton, B.A. Armstrong, S. Han, M.J. Mcarthy, J. Magn. Reson. 203 (1) (2010) 138-143
https://doi.org/10.1016/j.jmr.2009.12.012 PMID: 20045658.

Ultrasensitive Detection of Interfacial Water Diffusion on Lipid Vesicle Surfaces at Molecular Length Scales
R. Kausik, S. Han.
J. Am. Chem. Soc. 131 (51) (2009) 18254-18256
https://doi.org/10.1021/ja9060849 PMID: 19791740.

Dynamic Nuclear Polarization of 13C in Aqueous Solutions under Ambient Conditions
M.D. Lingwood, S. Han, J. Magn. Reson. 201 (2) (2009) 137-145
https://doi.org/10.1016/j.jmr.2009.09.002 PMID: 19783462.

Local Water Dynamics in Coacervated Polyelectrolytes Monitored through Dynamic Nuclear Polarization-Enhanced 1H NMR
R. Kausik, A. Srivastava, P.A. Korevaar, G. Stucky, J.H. Waite, S. Han, Macromolecules 42 (19) (2009) 7404–7412
https://doi.org/10.1021/ma901137g PMID: 20814445; PMCID: PMC2929756

Site-specific Dynamic Nuclear Polarization of Hydration Water as a Generally Applicable Approach to Monitor Protein Aggregation
A. Pavlova, E.R. McCarney, D.W. Peterson, F.W. Dahlquist, J. Lew, S. Han, Phys. Chem. Chem. Phys. (PCCP) 11 (2009) 6833-6839
https://doi.org/10.1039/b906101k PMID: 19639158; PMCID: PMC3153360

Overhauser Dynamic Nuclear Polarization and Molecular Dynamics Simulations using Pyrroline and Piperidine Ring Nitroxide Radicals
B.D. Armstrong, P. Soto, J. Shea, S. Han, J. Magn. Reson. 200 (2009) 137-141
https://doi.org/10.1016/j.jmr.2009.05.013 PMID: 19535275.

Overhauser Dynamic Nuclear Polarization To Study Local Water Dynamics
B.D. Armstrong, S. Han, J. Am. Chem. Soc. 131 (13) (2009) 4641-4647
https://doi.org/10.1021/ja809259q PMID: 19290661.

Study of Local Diffusion Coefficients of the Hydration Layer of Lipid Vesicle Bilayers
R. Kausik, B. D. Armstrong, S. Han, Diffusion Fundamentals 10 (2009) 27.1-27.4
https://doi.org/10.1021/ja4121692 PMCID: PMC3985948

Dynamic Nuclear Polarization Enhanced Nuclear Magnetic Resonance and Electron Spin Resonance Studies of Hydration and Local Water Dynamics in Micelle and Vesicle Assemblies
E. R. McCarney, B.D. Armstrong, R. Kausik, S. Han, Langmuir. 24 (18) (2008) 10062-10072
https://doi.org/10.1021/la800334k PMID: 18700788.

Dynamic Nuclear Polarization Studies of Local Water Dynamics in Soft Molecular Assemblies at 9.8 GHz 
S. Han, E. R. McCarney, B.D. Armstrong, Appl. Magn. Reson. 34 (3-4) (2008) 439-451
https://doi.org/10.1007/s00723-008-0135-3

Portable X-Band System for Solution State Dynamic Nuclear Polarization
B.D. Armstrong, M.D. Lingwood, E.R. McCarney, E.R. Brown, P. Blümler, S. Han, J. Magn. Reson. 191 (2) (2008)273-281
https://doi.org/10.1016/j.jmr.2008.01.004 PMID:18226943.

Spin-Labeled Gel for the Production of Radical-Free Dynamic Nuclear Polarization Enhanced Molecules for NMR Spectroscopy and Imaging
E.R. McCarney, S. Han, J. Magn. Reson. 190 (2) (2008) 307-315
https://doi.org/10.1016/j.jmr.2007.11.013

Local Hydration Dynamics in Soft Matter by Dynamic Nuclear Polarization of 1H-water
B. D. Armstrong, R. Kausik, S. Han, AIP Conf. Proc. 1081 (2008) 14-17
https://doi.org/10.1063/1.3058535

A New Model for Overhauser Enhanced Nuclear Magnetic Resonance Using Nitroxide Radicals
B. D. Armstrong, S. Han, J. Chem. Phys. 127 (10) (2007) 104508-10.
https://doi.org/10.1063/1.2770465

Hyperpolarized Water as an Authentic Magnetic Resonance Imaging Contrast Agent
E.R. McCarney, B. D. Armstrong, M. D. Lingwood, S. Han, Proc. Nat. Acad. Sci. USA. 104 (6) (2007) 1754-1759.
https://doi.org/10.1073/pnas.0610540104

para-Hydrogen-Induced Polarization in Heterogeneous Hydrogenation Reactions
I.V. Koptyug, K.V. Kovtunov, S.R. Burt, M.S. Anwar, C. Hilty, S. Han, A. Pines, R.Z. Sagdeev, J. Am. Chem. Soc.129 (17) (2007) 5580-5586
https://doi.org/10.1021/ja068653o

2007–2010 Book Chapters

Magnetic Resonance Microscopy
Edited by: S. Codd, J. Seymour
Wiley-VCH, Weinheim, Germany
Dynamic Nuclear Polarization-Enhanced Magnetic Resonance Analysis at X-band using Amplified 1H Water Signal 
S. Han., E.R. McCarney, B.D. Armstrong and M.D. Lingwood (Chapter 11)
https://doi.org/10.1002/9783527626052.ch11

Nuclear Magnetic Resonance Imaging
S. Stapf, S. Han
Ullmann Encyclopedia Article, Wiley-VCH, Germany, 2007

2000–2006 Journal Articles

Sensitivity Enhancement by Exchange Mediated Magnetization Transfer of the Xenon Biosensor Signal
S. Garcia, L. Chavez, T.J. Lowery, S. Han, D.E. Wemmer, A. Pines, J. Magn. Reson. 184 (2006) 72-77.
https://doi.org/10.1016/j.jmr.2006.09.010

Auxiliary Probe Design Adaptable to Existing Probes for Remote Detection NMR, MRI, and Time-of-Flight Tracing
S. Han, J. Granwehr, S. Garcia, E. McDonnell, A. Pines, J. Magn. Reson. 182 (2006) 260-272.
https://doi.org/10.1016/j.jmr.2006.06.024

SQUID-detected Microtesla MRI in the Presence of Metal
M. Mößle, S. Han, W. R. Myers, S. Lee, N. Kelso, M. Hatridge, A. Pines, J. Clarke, J. Magn. Reson. 179 (2006) 146-151. 
https://doi.org/10.1016/j.jmr.2005.11.005

NMR velocity mapping of gas flow around solid objects
S. Han, K. Pierce, A. Pines, Phys. Rev. E 74 (2006) 016302.
https://doi.org/10.1103/PhysRevE.74.016302

Improved NMR Based Bio-Sensing with Optimized Delivery of Polarized 129Xe to Solutions
S. Han, S. Garcia, T. J. Lowery, E. J. Ruiz, J.A. Seeley, L. Chavez, D. S. King, D. E. Wemmer, A. Pines, Anal. Chem. 77 (2005) 4008-4012.
https://doi.org/10.1021/ac0500479

NMR Analysis on Microfluidic Devices by Remote Detection
E. McDonnell, S. Han, C. Hilty, K. L. Pierce, A. Pines, Anal. Chem. 77 (24) (2005) 8109-8114.
https://doi.org/10.1021/ac051320+

Time-of-flight flow imaging using NMR Remote Detection
J. Granwehr, E. Harel, S. Han, S. Garcia, L. Chavez, A. Pines, Phys. Rev. Lett. 95 (2005) 075503.
https://doi.org/10.1103/PhysRevLett.95.075503

Microfluidic Gas Flow Profiling Using Hyperpolarized Xenon and Remote Detection
C. Hilty, E. McDonnell, J. Granwehr, K. Pierce, S. Han, A. Pines, Proc. Nat. Acad. Sci. 102 (2005) 14960-14963.
https://doi.org/10.1073/pnas.0507566102

Time Resolved Spectroscopic NMR Imaging Using Hyperpolarized 129-Xe
S. Han, H. Kühn, F. W. Häsing, K. Münnemann, B. Blümich, S. Appelt. J. Magn. Reson. 167 (2004) 298-305.

Imaging of a Mixture of Hyperpolarized He3 and Xe129
R.H. Acosta, P. Blümler, S. Han, S. Appelt, W. Häsing, J. Schmiedeskamp, W. Heil, H.W. Reson. Imag. 22 (2004) 1077-1083.

Proton Magnetic Resonance Imaging of Diffusion of High- and Low-Molecular-Weight Contrast Agents in Opaque Porous Media Saturated with Water
T. Osuga, S. Han. Magn. Reson. Imag. 22 (7) (2004) 1039-1042.

Three-Dimensional Phase-encoded Chemical Shift MRI in the Presence of Inhomogeneous Fields
V. Demas, D. Sakellariou, C. Meriles, S. Han, J. Reimer, A. Pines. Proc. Nat. Acad. Sci. 101 (24) (2004) 8845-8847.

Remotely-detected high-field MRI of Porous Samples
A. Seeley, S. Han, A. Pines. J. Magn. Reson. 167, 282-290 (2004).

Time Resolved Spectroscopic NMR Imaging Using Hyperpolarized 129-Xe
S. Han, H. Kühn, F. W. Häsing, K. Münnemann, B. Blümich, S. Appelt. J. Magn. Reson. 167, 298-305 (2004).

Remote Amplification of NMR Signal
A. J. Moule, M. Spence, S.-I Han, J.A. Seeley, K. Pierce, S. Saxena, A. Pines. Proc. Nat. Acad. Sci. 100 (16) (2003) 9122-9127.

Spectrally Resolved Velocity Exchange Spectroscopy of Two-Phase Flow
A. A. Khrapitchev, S.-I Han, S. Stapf, B. Blümich. J. Magn. Reson. 159, 36-45 (2002).

In Situ Observation of Diffusion and Reaction Dynamics in Gel Microreactors by Chemically Resolved NMR Microscopy
M. Küppers, C. Heine, S. Han, S. Stapf, B. Blümich. Appl. Magn. Reson. 22, 235-246 (2002).

Spatio-Temporal Correlations in Transport Processes Determined by Multi-PFG Experiments
S. Stapf, S. Han, C. Heine, B. Blümich. Concepts in Magn. Reson. 14 (3), 172-211 (2002).

NMR Imaging of Falling Drops
S. Han, S. Stapf, B. Blümich. Phys. Rev. Lett. 87 (14), 144501-144504 (2001).

Rheology of Blood by NMR
S. Han, O. Marseille, C. Gehlen, B. Blümich. J. Magn. Reson. 152 (2001) 87-94.

One-shot velocimetry using Echo Planar Imaging Microscopy
S. Han, P. T. Callaghan. J. Magn. Reson. 148 (2001) 349-354.

Two-Dimensional PFG-NMR for Encoding Correlations of Position, Velocity and Acceleration in Fluid Transport.
S. Han, S. Stapf, B. Blümich. J. Magn. Reson. 146, 169-180 (2000).

NMR Characterization of the Pore Structure and of Anisotropic Self-Diffusion in Salt Water Ice
M. I. Menzel, S. Han, S.Stapf, B. Blümich. J. Magn. Reson. 143, 376-381 (2000).

Two-Dimensional Representation of Position, Velocity and Acceleration by PFG-NMR
S. Han, B. Blümich. Appl. Magn. Reson. 18, 101-114 (2000).

2000–2006 Books and Book Chapters

Magnetic Resonance Imaging in Chemical Engineering
S. Stapf and S. Han.
Wiley-VCH, Weinheim, Germany (2006).

Fluid Flow and Trans-membrane Exchange in a Hemodialyzer Module
S. Han, S. Stapf.
in: S. Stapf, S. Han (Eds.) "NMR Imaging in Chemical Engineering" Wiley-VCH, Weinheim, Germany.

Broadening the application range of NMR and MRI by remote detection
S. Han, J. Granwehr, C. Hilty.
in: S. Stapf, S. Han (Eds.) "NMR Imaging in Chemical Engineering" Wiley-VCH, Weinheim, Germany.

2000–2006 Patents

Polarization Matrix for Producing Radical-Free Nuclear Spin Hyperpolarized Molecules as Contrast Agents.
S. Han, E.R. McCarney, B. D. Armstrong, M. D. Lingwood.
Provisional Patent (2006)

Remote NMR/MRI Detection of Laser Polarized Gases
Alex Pines, Sunil Saxena, Adam Moule, Megan Spence, Juliette Seeley, Kimberly Pierce, Song-I Han, Josef Grahnwehr
CIP U.S. Patent Application, IB-1771PCT, filed Oct. 9, 2002.