Spectroscopy of Biological and Materials Surfaces and Interactions


A concerted effort of the Han Group is the development of novel techniques and approaches, relying on electron and nuclear spin magnetic resonance that enables the study of biomolecular structure, dynamics and interaction with unprecedented sensitivity, resolution and information content. The Han Group relies on state of the art dynamic nuclear polarization (DNP)-enhanced nuclear magnetic resonance (NMR) spectroscopy and relaxometry, as well as electron paramagnetic resonance (EPR) tools. We are motivated by the power of “Seeing is Believing” to transform the study of biomolecular structure, molecular interactions, dynamics and functional processes with atomic and molecular-level insight.

Core questions of interest to the Han Group are directed towards:

  1. Magnetic Resonance Methods and Applications
  2. Tau Protein and Neurodegenerative Diseases
  3. Membrane Proteins Biophysics
  4. Hydration Water of Surfaces and Interfaces

In short, an ambitious and general goal of the laboratory is to turn NMR from a bulk to a surface characterization tool, and in doing so access entirely novel information content and research utility in materials science and the biochemistry/biophysics of complex biomolecular systems. Find out more about our current work in the research section, or click on the publications tab to see what has been done so far.

Find out more about Han lab news under the News tab. Follow us on Twitter @songihanlab.

Dr. Fichou's paper "Protein shapes at the core of chronic traumatic encephalopathy" has been published in Nature Structural & Molecular Biology.

The Biophysical Society (BPS) has named Professor Songi Han its 2019 Innovation Award winner. Prof. Han was honored at the Society’s 63rd Annual Meeting at the Baltimore Convention Center on March 5, 2019, during the annual Awards Symposium.

New insight from the Han Lab into the mechanism of tau protein aggregation could lead to better in vitro models for neurodegenerative disease research.