Hydration Water

2021 Journal Articles

P-Site Structural Diversity and Evolution in a Zeosil Catalyst
S. K. Jain, T. Tabassum, L. Li, L. Ren, W. Fan, M. Tsapatsis, S. Caratzoulas, S. Han, and S. Scott. J. Am. Chem. Soc., 143(4) (2021), 1968-1983
https://doi.org/10.1021/jacs.0c11768. PMID: 33491456.

2020 Journal Articles

End-to-End Distance Probability Distributions of Dilute Poly(ethylene oxide) in Aqueous Solution
N. Sherck, T. Webber, D. R. Brown, T. Keller, M. Barry, A. DeStefano, S. Jiao, R. A. Segalman, G. H. Fredrickson, M. S. Shell, and S. Han J. Am. Chem. Soc., 142(46) (2020), 19631-19641.
https://doi.org/10.1021/jacs.0c08709. PMID: 33141567.
Spotlighted on Recent JACS Publications.

Tuning molecular adsorption in SBA-15-type periodic mesoporous organosilicas by systematic variation of their surface polarity
H. Moon, S. Han, and S. Scott. Chem. Sci., 11 (2020), 3702-3712 
https://doi.org/10.1039/D0SC00168F. PMID: 33209241; PMCID: PMC7643544.

Water Structure and Properties at Hydrophilic and Hydrophobic Surfaces
J. Monroe, M. Barry, A. DeStefano, P. A. Gorturk, S. Jiao, D. Robinson-Brown, T. Webber, E. J. Crumlin, S. Han, and S. Shell. Annu. Rev. Chem. Biomol. Eng., 11 (2020), 523-557.
https://doi.org/10.1146/annurev-chembioeng-120919-114657. PMID: 32169001.

The Role of Backbone Polarity on Aggregation and Conduction of Ions in Polymer Electrolytes
N. S. Schauser, D. J. Grzetic, T. Tabassum, G. A. Kliegle, M. L. Le, E. M. Susca, S. Antoine, T. J. Keller, K. T. Delaney, S. Han, R. Seshadri, G. H. Fredrickson, R. A. Segalman J. Am. Chem. Soc., 142 (15) (2020), 7055-7065
https://doi.org/10.1021/jacs.0c00587. PMID: 32243146.

Phosphonate‐Modified UiO‐66 Brønsted Acid Catalyst and Its Use in Dehydra‐Decyclization of 2‐Methyltetrahydrofuran to Pentadienes
M. D. de Mello, G. Kumar, T. Tabassum, S. K. Jain, T.-H. Chen, S. Caratzoulas, X. Li, D. G. Vlachos, S. Han, S. L. Scott, P. Dauenhauer, and M. Tsapatsis. Angew. Chem., 59 (2020), 2-9.
https://doi.org/10.1002/ange.202001332. PMID: 32413202.

2019 Journal Articles

Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms
M. Lin, N. K. Pandey, R. Barnes, S. Han, and R. Langen. Structure, 27 (10) (2019), 1570-1580.e4.
https://doi.org/10.1016/j.str.2019.08.003. PMID: 31466833; PMCID: PMC6774876.

Anomalous solute diffusivity in ionic liquids: Label-free visualization and physical origins
A. V. Bayles, C. S. Valentine, T. Überrück, S. P. O. Danielsen, S. Han, M. E. Helgeson, T. M. Squires. Phys. Rev. X, 9 (2018), 011048.

2019 Book Chapter

Methods in Enzymology: Biological NMR Part B
Vol. 615, Elsevier Inc. (2019), 131-175.

Chapter Five - Overhauser Dynamic Nuclear Polarization for the Study of Hydration Dynamics, Explained
J. M. Franck and S. Han
https://doi.org/10.1016/bs.mie.2018.09.024. PMID: 30638529.

2018 Journal Articles

Effect of nitroxide spin probes on the transport properties of Nafion membranes
T. Überrück, O. Neudert, K.-D. Kreuer, B. Blümich, J. Granwehr, S. Stapf, S. Han. Phys. Chem. Chem. Phys., 20 (2018), 26660-26674.

Heterogeneity of network structure and water dynamics in K-carrageenan gels probed by nanoparticle diffusometry
D. de Kort, E. Schuster, F. Hoeben, R. Barnes, M. Emondts, H. Janssen, N. Lorén, S. Han, H. van As, J. van Duynhoven. Langmuir, 34 (37) (2018), 11110-11120.

Functionally Active Membrane Proteins Incorporated in Mesostructured Silica Films
J. P. Jahnke, M. N. Idso, S. Hussain, M. J. N. Junk, J. M. Fisher, D. D. Phan, S. Han, B. F. Chmelka, J. Am. Chem. Soc., 140 (11) (2018), 3892-3906.
https://doi.org/10.1021/jacs.7b06863. PMID: 29533066; PMCID: PMC6040920.

Surface Chemical Heterogeneity Modulates Silica Surface Hydration
A. M. Schrader, J. I. Monroe, R. Sheil, H. A. Dobbs, T. J. Keller, Y. Li, S. Jain, M. S. Shell, J. V. Israelachvili, S. Han, Proc. Natl. Acad. Sci. U.S.A., 115 (12) (2018) 2890-2895.
https://doi.org/10.1073/pnas.1722263115. PMID: 29507240; PMCID: PMC5866604.
Highlighted in the UC Santa Barbara Current:

Perspective of Overhauser Dynamic Nuclear Polarization for the Study of Soft Materials
R. Barnes, S. Han, J. Biller, Curr. Opin. Colloid Interface Sci., 33(2018), 72-85.

2017 Journal Articles

Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium
R. Barnes, S. Sun, Y. Fichou, F.W. Dahlquist, M. Heyden, S. Han, J. Am. Chem. Soc., 139 (49) (2017) 17890-17901.
https://doi.org/10.1021/jacs.7b08606. PMID: 29091442; PMCID: PMC6021025.
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/49

Simple peptide coacervates adapted for rapid pressure-sensitive wet adhesion
I. Kaminker, W. Wei, A.M. Schrader, Y. Talmon, M.T. Valentine, J.N. Israelachvili, J.H. Waite, S. Han, Soft Matter., 13 (48) (2017) 9122-9131.
https://doi.org/10.1039/C7SM01915G. PMID: 29192930; PMCID: PMC5744669.

Universal Dynamics of Molecular Reorientation in Hybrid Lead Iodide Perovskites
D.H Fabini, T.A. Siaw, C.C. Stoumpos, G. Laurita, D. Olds, K. Page, J.G. Hu, M.G. Kanatzidis, S. Han, R. Seshadri, J. Am. Chem. Soc., 139 (46) (2017) 16875-16884.
https://doi.org/10.1021/jacs.7b09536. PMID: 29094934.
Highlighted Cover Article: http://pubs.acs.org/toc/jacsat/139/46

Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure
J.H. Ortony, B. Qiao, C.J. Newcomb, T.J. Keller, L.C. Palmer, E. Deiss-Yehiely, M.O. Cruz S. Han, S.I. Stupp, J. Am. Chem. Soc., 139 (26) (2017) 8915–8921
https://doi.org/10.1021/jacs.7b02969. PMID: 28636349.
Highlighted in Nature Chemistry News and Views: http://doi.org/10.1038/nchem.2870

2016 Journal Articles

Hydration dynamics of a peripheral membrane protein
O. Fisette, C. Paslack, R. Barnes, J.M. Isas, R. Langen, M. Heyden, S. Han, L.V. Schafer, J. Am Chem. Soc., 138 (2016) 11526-11535
https://doi.org/10.1021/jacs.6b07005 PMID: 27548572; PMCID: PMC5519773.

Contrasting Effects of Glycerol and DMSO on Lipid Membrane Surface Hydration Dynamics and Forces
A. Schrader, C. Cheng, J. Israelachvili, S. Han, J. Chem. Phys., 145 (2016) 041101
https://doi.org/10.1063/1.4959904 PMID: 27475340; PMCID: PMC4967073.

Stability of protein-specific hydration shell on crowding
K. Huang, C.N. Kingsley, R. Sheil, C. Cheng, J.B. Bierma, K.W. Roskamp, D. Khago, R.W. Martin, S. Han, J. Am. Chem. Soc., 138 (16) (2016) 5392–5402
https://doi.org/10.1021/jacs.6b01989. PMID: 27052457; PMCID: PMC7849722.

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau
A. Pavlova, C. Cheng, M. Kinnebrew, J. Lew, F. Dahlquist, S. Han, Proc. Natl. Acad. Sci., 113 (2) (2016) E127-E136
https://doi.org/10.1073/pnas.1504415113 PMCID: PMC4720316

2015 Journal Articles

Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?
P. Stals, C. Cheng, L. Beek, A. Wauters, A. Palmans, S. Han, E. Meijer, Chem. Sci., 7 (2015) 2011-2015

Anomalously rapid hydration water diffusion dynamics near DNA surfaces
J. Franck, Y. Ding, K. Stone, P. Qin, S. Han, J. Am. Chem. Soc., 137 (37) (2015) 12013-12023
https://doi.org/ 10.1021/jacs.5b05813 PMID: 26256693; PMCID: PMC4656248

Correlating steric-hydration forces with water dynamics through surface force and diffusion NMR measurements in a lipid-DMSO-H2O system
A. Schrader, S. Donaldson, J. Song, C. Cheng, D. Lee, S. Han, J. Israelachvili, Proc. Natl. Acad. Sci., 112 (34) (2015) 10708–10713
https://doi.org/10.1073/pnas.1512325112 PMID: 26261313; PMCID: PMC4553805

DMSO induces dehydration near lipid membrane surfaces
C. Cheng, J. Song, J. Pas, L. Meijer, S. Han, Biophys. J., 109 (2) (2015) 330-339
https://doi.org/10.1016/j.bpj.2015.06.011 PMID: 26200868; PMCID: PMC4621616

Ion specific effects: decoupling ion-ion and ion-water interactions
J. Song, M. Kim, T. Kang, S. Han, Phys. Chem. Chem. Phys., 17 (2015) 8306-8322
https://doi.org/10.1039/C4CP05992A PMID: 25761273; PMCID: PMC4656249

Nanometer-Scale Water and Proton Diffusion Heterogeneities across Water Channels in Polymer Electrolyte Membranes
J. Song, O. H. Han,  S. Han, Angew. Chem., 54 (12) (2015) 3615-3620
https://doi.org/10.1002/anie.201408318 PMID: 25630609; PMCID: PMC4450673

2015 Book Chapters

Methods in Enzymology: Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions - Part B
Edited by: P. Z. Qin, K. Warncke

Vol. 564, Elsevier Inc. (2015)
Overhauser Dynamic Nuclear Polarization Studies on Local Water Dynamics
I. Kaminker, R. Barnes, and S. Han
https://doi.org/10.1016/bs.mie.2015.06.040 PMID: 26477261

Protein NMR - Modern Techniques and Biomedical Applications
Edited by: Lawrence Berliner

Vol. 32, Springer (2015) 43-74
Mapping Out Protein Hydration Dynamics by Overhauser Dynamic Nuclear Polarization
C. Cheng, J. Song, J. Franck, S. Han

2014 Journal Articles

Local water diffusivity as a molecular probe of surface hydrophilicity 
J. Song, B. Allison, S. Han, MRS Bull., 39 (12) (2014) 1082-1088

Cholesterol Enhances Surface Water Diffusion of Phospholipid Bilayers
C. Y. Cheng, L. Olijve, R. Kausik, S. Han, J. Chem. Phys., 141 (22D513) (2014)
https://doi.org/10.1063/1.4897539 PMID: 25494784; PMCID: PMC4201661

Intrinsic Surface-Drying Properties of Bioadhesive Proteins
Y. Akdogan, W. Wei, K. Huang, Y. Kageyama, E. W. Danner, D. R. Miller, N. R. Martinez Rodriguez, J. H. Waite, S. Han, Angew. Chem., 126 (42) (2014) 11435-11438
https://doi.org/10.1002/ange.201406858 PMID: 25168789; PMCID: PMC4198389
Featured in Nature Materials | Research Highlights

Probing water density and dynamics in the chaperonin GroEL cavity
J. Franck, M. Sokolovski, N. Kessler, E. Matalon, M. Gordon-Grossman, S. Han, D. Goldfarb, A. Horovitz, J. Am. Chem. Soc., 136 (26) (2014) 9396-9403
https://doi.org/10.1021/ja503501x PMID: 24888581; PMCID: PMC4091268

Specific Ions Modulate Diffusion Dynamics of Hydration Water on Lipid Membrane Surfaces
J. Song, J. Franck, P. Pincus, M.W. Kim, S. Han, J. Am. Chem. Soc., 136 (6) (2014) 2642-2649
https://doi.org/10.1021/ja4121692 PMID: 24456096; PMCID: PMC3985948

2013 Journal Articles

Fluidity and Water in Nanoscale Domains Define Coacervate Hydrogels
J.H. Ortony, S.H. Choi, J.M. Spruell, J.N. Hunt, N.A. Lynd, D.V. Krogstad, V.S. Urban, C.J. Hawker, E.J. Kramer, S. Han, Chemical Sciences 5 (2013) 58-67

Hydration Dynamics as an Intrinsic Ruler for Refining Protein Structure at Lipid Membrane Interfaces
C.Y. Cheng, J. Varkey, M.R. Ambroso, R. Langen, S. Han, Proc. Natl. Acad. Sci. 110 (42) (2013) 16838–16843
https://doi.org/10.1073/pnas.1307678110 PMID: 24082088; PMCID: PMC3800990

Quantitative cw Overhauser Dynamic Nuclear Polarization for the Analysis of Local Water Dynamics
J. M. Franck, A. Pavlova, J.A. Scott, S. Han, Prog. Nucl. Magn. Reson. 74 (2013) 33-56
https://doi.org/10.1016/j.pnmrs.2013.06.001 PMID: 24083461; PMCID: PMC3798041

Asymmetric Collapse in Biomimetic Complex Coacervates Revealed by Local Polymer and Water Dynamics
J.H. Ortony, D.S. Hwang, J.M. Franck, J.H. Waite, S. Han, Biomacromolecules, 14(5) (2013) 1395-1402
https://doi.org/10.1021/bm4000579 PMID: 23540713; PMCID: PMC4090114

Nonlinear Scaling of Surface Water Diffusion with Bulk Water Viscosity of Crowded Solutions
J.M. Franck, J.A. Scott, S. Han, J. Am. Chem. Soc., 135(11) (2013) 4175-4178
https://doi.org/10.1021/ja3112912 PMID: 23347324; PMCID: PMC3785640.

Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics
S. Hussain, J. M. Franck, S. Han, Angew. Chem. Int. Ed., 52(7) (2013) 1953-1958
https://doi.org/10.1002/anie.201206147 PMID: 23307344

2012 Journal Articles

Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: The Role of Hydration Dynamics Revealed by Dynamic Nuclear Polarization
C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, Biomacromolecules, 13(9) (2012) 2624-2633
https://doi.org/10.1021/bm300848c PMID: 22808941.

Hyperpolarized Water as an MRI Contrast Agent
M. D. Lingwood, T. Siaw, N. Sailasuta, O. A. Abulseoud, H. R. Chan, B. D. Ross, P. Bhattacharya, S. Han, , Radiology, 265 (3) (2012) 418-425
https://doi.org/ 10.1148/radiol.1211180 PMID: 22996746; PMCID: PMC3480810.

An ultrasensitive tool exploiting hydration dynamics to decipher weak lipid membrane–polymer interactions
C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, J. Magn. Reson. 215 (2012) 115-119
https://doi.org/10.1016/j.jmr.2011.12.004 PMID: 22230738.

2011 Journal Articles

Site-Specific Hydration Dynamics in the Nonpolar Core of a Molten Globule by Dynamic Nuclear Polarization of Water
B.D. Armstrong, J. Choi, C. Lopez, D. A. Wesener, W. Hubbell, S. Cavagnero, S. Han, J. Am. Chem. Soc.133 (2011) 5987–5995
https://doi.org/10.1021/ja111515s PMID: 21443207; PMCID: PMC3095581

Dynamics and State of Lipid Bilayer-internal Water Unraveled with Solution State 1H Dynamic Nuclear Polarization
R. Kausik, S. Han, Phys. Chem. Chem. Phys. (2011) 13, 7732-7746
https://doi.org/10.1039/c0cp02512g PMID: 21423982.

Probing the Hydration Water Diffusion of Macromolecular Surfaces and Interfaces
J. H. Ortony, C.-Y. Cheng, R. Kausik, A. Pavlova, J. Hunt, S. Han, New J. Phys.13 (2011) 015006 (15pp)

2007–2010 Journal Articles

Continuous Flow Overhauser Dynamic Nuclear Polarization of Water in the Fringe Field of a Clinical Magnetic Resonance Imaging System for Authentic Image Contrast
M. D. Lingwood, T. A. Siaw, N. Sailasuta, B. D. Ross, P. Bhattacharya and S. Han, J. Magn. Reson. 205 (2) (2010) 247-254
https://doi.org/10.1016/j.jmr.2010.05.008 PMID: 20541445; PMCID: PMC4724375.

Ultrasensitive Detection of Interfacial Water Diffusion on Lipid Vesicle Surfaces at Molecular Length Scales
R. Kausik, S. Han.
J. Am. Chem. Soc. 131 (51) (2009) 18254-18256
https://doi.org/10.1021/ja9060849 PMID: 19791740.

Local Water Dynamics in Coacervated Polyelectrolytes Monitored through Dynamic Nuclear Polarization-Enhanced 1H NMR
R. Kausik, A. Srivastava, P.A. Korevaar, G. Stucky, J.H. Waite, S. Han, Macromolecules 42 (19) (2009) 7404–7412
https://doi.org/10.1021/ma901137g PMID: 20814445; PMCID: PMC2929756

Site-specific Dynamic Nuclear Polarization of Hydration Water as a Generally Applicable Approach to Monitor Protein Aggregation
A. Pavlova, E.R. McCarney, D.W. Peterson, F.W. Dahlquist, J. Lew, S. Han, Phys. Chem. Chem. Phys. (PCCP) 11 (2009) 6833-6839
https://doi.org/10.1039/b906101k PMID: 19639158; PMCID: PMC3153360

Overhauser Dynamic Nuclear Polarization To Study Local Water Dynamics
B.D. Armstrong, S. Han, J. Am. Chem. Soc. 131 (13) (2009) 4641-4647
https://doi.org/10.1021/ja809259q PMID: 19290661.

Study of Local Diffusion Coefficients of the Hydration Layer of Lipid Vesicle Bilayers
R. Kausik, B. D. Armstrong, S. Han, Diffusion Fundamentals 10 (2009) 27.1-27.4
https://doi.org/10.1021/ja4121692 PMCID: PMC3985948

Dynamic Nuclear Polarization Enhanced Nuclear Magnetic Resonance and Electron Spin Resonance Studies of Hydration and Local Water Dynamics in Micelle and Vesicle Assemblies
E. R. McCarney, B.D. Armstrong, R. Kausik, S. Han, Langmuir. 24 (18) (2008) 10062-10072
https://doi.org/10.1021/la800334k PMID: 18700788.

Dynamic Nuclear Polarization Studies of Local Water Dynamics in Soft Molecular Assemblies at 9.8 GHz 
S. Han, E. R. McCarney, B.D. Armstrong, Appl. Magn. Reson. 34 (3-4) (2008) 439-451

Local Hydration Dynamics in Soft Matter by Dynamic Nuclear Polarization of 1H-water
B. D. Armstrong, R. Kausik, S. Han, AIP Conf. Proc. 1081 (2008) 14-17

Hyperpolarized Water as an Authentic Magnetic Resonance Imaging Contrast Agent
E.R. McCarney, B. D. Armstrong, M. D. Lingwood, S. Han, Proc. Nat. Acad. Sci. USA. 104 (6) (2007) 1754-1759.

para-Hydrogen-Induced Polarization in Heterogeneous Hydrogenation Reactions
I.V. Koptyug, K.V. Kovtunov, S.R. Burt, M.S. Anwar, C. Hilty, S. Han, A. Pines, R.Z. Sagdeev, J. Am. Chem. Soc.129 (17) (2007) 5580-5586

2007–2010 Book Chapter

Magnetic Resonance Microscopy
Edited by: S. Codd, J. Seymour
Wiley-VCH, Weinheim, Germany
Dynamic Nuclear Polarization-Enhanced Magnetic Resonance Analysis at X-band using Amplified 1H Water Signal 
S. Han., E.R. McCarney, B.D. Armstrong and M.D. Lingwood (Chapter 11)