Electron & Nuclear Spins

2020 Journal Articles

Balancing Dipolar and Exchange coupling in Biradicals to Maximize Cross Effect Dynamic Nuclear Polarization
A. Equbal, K. Tagami, and S. Han Phys. Chem. Chem. Phys. (2020)

Crossover from a Solid Effect to Thermal Mixing 1H Dynamic Nuclear Polarization with Trityl-OX063
A. Equbal, Y. Li, T. Tabassum, and S. Han J. Phys. Chem. Lett. (2020)

2019 Journal Articles

Tracing Dynamic Nuclear Polarization Pathways Using Transition Metal - Nuclear Spin Rulers
S. K. Jain, C.-J. Yu, B. Wilson, T. Tabassum, D. E. Freedman, and S. Han. ChemRxiv (2019)

Pulse Shaped Dynamic Nuclear Polarization Under Magic Angle Spinning
A. Equbal, K. Tagami, and S. Han. J. Phys. Chem. Lett., 10 (2019), 7781-7788.
Also published in ChemRxiv: 
Live Video Presentation on the topic can be found here.

Electron Spin Density Matching for Cross-Effect Dynamic Nuclear Polarization
Y. Li, A. Equbal, K. Tagami, and S. Han. Chem. Commun., 55 (2019), 7591-7594.

Biradical rotamer states tune electron J coupling and MAS dynamic nuclear polarization enhancement
K. Tagami, A. Equbal, I. Kaminker, B. Kirtman, and S. Han Solid State Nucl. Mag. Res., 101 (2019), 12-20.

Cross-Effect Dynamic Nuclear Polarization Explained: Polarization, Depolarization, and Oversaturation
A. Equbal, A. Leavesley, S. K. Jain, S. Han. J. Phys. Chem. Lett., 10 (2019), 548-558.
Content of this publication inspired design of cover art of entailing journal issue.

2018 Journal Articles

Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities
A. Leavesley, I. Kaminker, S. Han. eMagRes, 7 (2018), 133-154.
Included as part of the "Handbook of High Frequency Dynamic Nuclear Polarization NMR" series.

Maximizing NMR signal per unit time by facilitating the e-e-n cross effect DNP rate
A. Leavesley, S. Jain, I. Kaminker, H. Zhang, S. Rajca, A. Rajca, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 27646-27654.
https://doi.org/10.1039/C8CP04909B. PMID: 30375593. PMCID: PMC6370975. NIHMSID: NIHMS995519.
Selected 2018 PCCP Hot Article

Tuning nuclear depolarization under MAS by electron T1e
A. Lund, A. Equbal, S. Han. Phys. Chem. Chem. Phys. 20 (2018), 23976-23987.
https://doi.org/10.1039/C8CP04167A. PMID: 30211922. PMCID: PMC6208319. NIHMSID: NIHMS989193.
Selected 2018 PCCP Hot Article

Multi-step phase-cycling in a free-electron laser-powered pulsed electron paramagnetic resonance spectrometer
C. B. Wilson, S. Aronson, J. A. Clayton, S. J. Glaser, S. Han, M. S. Sherwin. Phys. Chem. Chem. Phys., 20 (2018), 18097-18109.

Amplification of Dynamic Nuclear Polarization at 200 GHz by Arbitrary Pulse Shaping of the Electron Spin Saturation Profile
I. Kaminker, S. Han. J. Phys. Chem. Lett., 9 (11) (2018), 3110-3115.

Truncated Cross Effect Dynamic Nuclear Polarization: An Overhauser Effect Doppelgänger
A. Equbal, Y. Li, A. Leavesley, S. Huang, S. Rajca, A. Rajca, S. Han, J. Phys. Chem. Lett., 9 (9) (2018), 2175-2180.

Quantitative analysis of zero-field splitting parameter distributions in Gd(III) complexes
J. A. Clayton, K. Keller, M. Qi, J. Wegner, V. Koch, H. Hintz, A. Godt, S. Han, G. Jeschke, M. S. Sherwin, M. Yulikov, Phys. Chem. Chem. Phys., 20 (15) (2018), 10470-10492.
https://doi.org/10.1039/c7cp08507a. PMID: 29617015. PMCID: PMC6026474.

Effect of Water/Glycerol Polymorphism on Dynamic Nuclear Polarization
A. Leavesley, C. B. Wilson, M. Sherwin, S. Han, Phys. Chem. Chem. Phys, 20 (15) (2018), 9897-9903.

Reversal of Paramagnetic Effects by Electron Spin Saturation
S. K. Jain, T. A. Siaw, A. Equbal, C. B. Wilson, I. Kaminker, S. Han, J. Phys. Chem. C, 122 (10) (2018), 5578-5589.

2017 Journal Articles

Arbitrary waveform modulated pulse EPR at 200 GHz
I. Kaminker, R. Barnes, S. Han, J. Magn. Reson., 279 (2017) 81-90
https://doi.org/10.1016/j.jmr.2017.04.016. PMID: 28482216. PMCID: PMC5519772

Gd3+-Gd3+ distances exceeding 3 nm determined by very high frequency continuous wave electron paramagnetic resonance
J.A. Clayton, M. Qi, A. Godt, D. Goldfarb, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 19 (7) (2017)5127-5136
https://doi.org/10.1039/C6CP07119H. PMID: 28139788. PMCID: PMC5394103

Effect of electron spectral diffusion on static dynamic nuclear polarization at 7 Tesla
A. Leavesley, D. Shimon, T. Siaw, A. Feintuch, D. Goldfarb, S. Vega, I. Kaminker, S. Han, Phys. Chem. Chem. Phys., 19 (5)(2017) 3596-3605.
https://doi.org/10.1039/C6CP06893F. PMID: 28094364

2016 Journal Articles

A versatile and modular quasi optics-based 200 GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument
T.A. Siaw, A. Leavesley, A. Lund, I. Kaminker, S. Han, J. Magn. Reson., 264 (2016) 131-153
https://doi.org/10.1016/j.jmr.2015.12.012 PMCID: PMC4770585.

2015 Journal Articles

Direct Dynamic Nuclear Polarization Targeting Catalytically Active 27Al Sites
A. Lund, M. Hsieh, T. Siaw, S. Han, Phys. Chem. Chem. Phys., 17 (2015) 25449-25454
https://doi.org/10.1039/C5CP03396A PMID: 26365719

Active Cancellation - A Means to Zero Dead-Time Pulse EPR
J. Franck, R. Barnes, T. Keller, T. Kaufmann, S. Han, J. Magn. Reson., 261 (2015) 199-204
https://doi.org/10.1016/j.jmr.2015.07.005 PMID: 26507308; PMCID: PMC4688155

2014 Journal Articles

Role of Electron Spin Dynamics on Solid-State Dynamic Nuclear Polarization Performance
T. Siaw, M. Fehr, A. Lund, A. Latimer, S. Walker D. Edwards, S. Han, Phys. Chem. Chem. Phys., 16 (2014) 18694-18706.
https://doi.org/10.1039/C4CP02013H PMID: 24968276.

2013 Journal Articles

DAC-board based X-band EPR Spectrometer with Arbitrary Waveform Control (w/Audio Slide Presentation)
T. Kaufmann, T.J. Keller, J.M. Franck, R.P. Barnes, S.J. Glaser, J.M. Martinis, S. Han, J. Magn. Reson. 235 (2013) 95-108
https://doi.org/10.1016/j.jmr.2013.07.015 PMID: 23999530; PMCID: PMC3863685

Temperature Dependence of High Field 13C Dynamic Nuclear Polarization Processes below 35 Kelvin
S.A. Walker, D.T. Edwards, T. Siaw, B.D. Armstrong, S. Han, Phys. Chem. Chem. Phys. 15 (36) (2013) 15106-15120
https://doi.org/10.1039/C3CP51628H PMID: 23925724.

Extending the Distance Range Accessed with Continuous Wave EPR with Gd3+ Spin Probes at High Magnetic Fields
D.T. Edwards, Z. Ma, T.J. Meade, D. Goldfarb, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 15 (2013) 11313-11326
https://doi.org/10.1039/C3CP43787F PMID: 23732863; PMCID: PMC4142211

Overhauser Dynamic Nuclear Polarization-Enhanced NMR Relaxometry
J.M. Franck, R. Kausik, S. Han, Microporous and Mesoporous Materials, 178 (2013) 113-118
https://doi.org/10.1016/j.micromeso.2013.04.019 PMID: 23837010; PMCID: PMC3702190

Phase Cycling with a 240 GHz Free Electron Laser-powered Electron Paramagnetic Resonance Spectrometer
D.T. Edwards, Y. Zhang, S.J. Glaser, S. Han, M.S. Sherwin, Phys. Chem. Chem. Phys., 15 (2013) 5707-5719
https://doi.org/10.1039/C3CP44492A PMID: 23474874.

Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics
S. Hussain, J. M. Franck, S. Han, Angew. Chem. Int. Ed., 52(7) (2013) 1953-1958
https://doi.org/10.1002/anie.201206147 PMID: 23307344

2013 Journal Articles

Annual Review of Physical Chemistry
Vol. 64, Annual Reviews (2013)
Dynamic Nuclear Polarization Methods in Solids and Solutions to Explore Membrane Proteins and Membrane Systems
C. Cheng and S. Han
https://doi.org/10.1146/annurev-physchem-040412-110028 PMID: 23331309

2012 Journal Articles

Quantitative Analysis of Molecular Transport across Liposomal Bilayer by J-mediated 13C Dynamic Nuclear Polarization
C.Y. Cheng, J.G.M.O. Goor, S. Han, Anal. Chem., 84(21) (2012) 3936-3940
https://doi.org/10.1021/ac301932h PMID: 23072518; PMC4656247.

Distance measurements across randomly distributed nitroxide probes from the temperature dependence of the electron spin phase memory time at 240 GHz
D.T. Edwards, S. Takahashi, M. S. Sherwin, S. Han, J. Magn. Reson., 223 (2012) 198-206
https://doi.org/10.1016/j.jmr.2012.07.004 PMID: 22975249.

Inductively coupled NMR probe for versatile dynamic nuclear polarization operation at 7 Tesla: observation of 61 ± 2% 1H polarization at 4 K
T. Siaw, S. A. Walker, B. D. Armstrong, S. Han, J. Magn. Reson., 221 (2012) 5-10
https://doi.org/10.1016/j.jmr.2012.05.017 PMID: 22743536.

Pulsed electron paramagnetic resonance spectroscopy powered by a free-electron laser
S. Takahashi, L.-C. Brunel, D. T. Edwards, J. van Tol, G. Ramian, S. Han, M. S. Sherwin, Nature 489 (74160) (2012)409-13
https://doi.org/10.1038/nature11437 PMID: 22996555.

Overhauser dynamic nuclear polarization amplification of NMR flow imaging
M. D. Lingwood, A. J. Sederman, M. D. Mantle, L. F. Gladden, S. Han, J. Magn. Reson. 216 (2012) 94–100

2011 Book Chapters

Annual Reports on NMR Spectroscopy
Edited by: Graham A. Webb

Vol. 73, Elsevier Academic Press (2011)
Solution State Dynamics Nuclear Polarization 
M. D. Lingwood, S. Han. (Pages 83-126)
https://doi.org/10.1016/B978-0-08-097074-5.00003-7 PMID: 12137529

2007–2010 Journal Articles

A 200 GHz Dynamic Nuclear Polarization Spectrometer
B.D. Armstrong, D.T. Edwards, R.J. Wylde, S.A. Walker, S. Han, Phys. Chem. Chem. Phys., 12 (2010) 5920-5926
https://doi.org/10.1039/c002290j PMID: 20461268.

Heisenberg Spin Exchange Effects of Nitroxide Radicals on Overhauser Dynamic Nuclear Polarization in the Low Field Limit at 1.5 mT
M.D. Lingwood, I.A. Ivanov, A.R. Cote, S. Han, J. Magn. Reson. 204 (1) (2010) 56-63
https://doi.org/10.1016/j.jmr.2010.01.015 PMID: 20188611.

L-band Overhauser dynamic nuclear polarization
S. Garcia, J.H. Walton, B.A. Armstrong, S. Han, M.J. Mcarthy, J. Magn. Reson. 203 (1) (2010) 138-143
https://doi.org/10.1016/j.jmr.2009.12.012 PMID: 20045658.

Dynamic Nuclear Polarization of 13C in Aqueous Solutions under Ambient Conditions
M.D. Lingwood, S. Han, J. Magn. Reson. 201 (2) (2009) 137-145
https://doi.org/10.1016/j.jmr.2009.09.002 PMID: 19783462.

Overhauser Dynamic Nuclear Polarization and Molecular Dynamics Simulations using Pyrroline and Piperidine Ring Nitroxide Radicals
B.D. Armstrong, P. Soto, J. Shea, S. Han, J. Magn. Reson. 200 (2009) 137-141
https://doi.org/10.1016/j.jmr.2009.05.013 PMID: 19535275.

Portable X-Band System for Solution State Dynamic Nuclear Polarization
B.D. Armstrong, M.D. Lingwood, E.R. McCarney, E.R. Brown, P. Blümler, S. Han, J. Magn. Reson. 191 (2) (2008)273-281
https://doi.org/10.1016/j.jmr.2008.01.004 PMID:18226943.

Spin-Labeled Gel for the Production of Radical-Free Dynamic Nuclear Polarization Enhanced Molecules for NMR Spectroscopy and Imaging
E.R. McCarney, S. Han, J. Magn. Reson. 190 (2) (2008) 307-315

A New Model for Overhauser Enhanced Nuclear Magnetic Resonance Using Nitroxide Radicals
B. D. Armstrong, S. Han, J. Chem. Phys. 127 (10) (2007) 104508-10.

2007–2010 Book Chapter

Nuclear Magnetic Resonance Imaging
S. Stapf, S. Han
Ullmann Encyclopedia Article, Wiley-VCH, Germany, 2007

2000–2006 Journal Articles

Sensitivity Enhancement by Exchange Mediated Magnetization Transfer of the Xenon Biosensor Signal
S. Garcia, L. Chavez, T.J. Lowery, S. Han, D.E. Wemmer, A. Pines, J. Magn. Reson. 184 (2006) 72-77.

Auxiliary Probe Design Adaptable to Existing Probes for Remote Detection NMR, MRI, and Time-of-Flight Tracing
S. Han, J. Granwehr, S. Garcia, E. McDonnell, A. Pines, J. Magn. Reson. 182 (2006) 260-272.

SQUID-detected Microtesla MRI in the Presence of Metal
M. Mößle, S. Han, W. R. Myers, S. Lee, N. Kelso, M. Hatridge, A. Pines, J. Clarke, J. Magn. Reson. 179 (2006) 146-151. 

NMR velocity mapping of gas flow around solid objects
S. Han, K. Pierce, A. Pines, Phys. Rev. E 74 (2006) 016302.

Improved NMR Based Bio-Sensing with Optimized Delivery of Polarized 129Xe to Solutions
S. Han, S. Garcia, T. J. Lowery, E. J. Ruiz, J.A. Seeley, L. Chavez, D. S. King, D. E. Wemmer, A. Pines, Anal. Chem. 77 (2005) 4008-4012.

NMR Analysis on Microfluidic Devices by Remote Detection
E. McDonnell, S. Han, C. Hilty, K. L. Pierce, A. Pines, Anal. Chem. 77 (24) (2005) 8109-8114.

Time-of-flight flow imaging using NMR Remote Detection
J. Granwehr, E. Harel, S. Han, S. Garcia, L. Chavez, A. Pines, Phys. Rev. Lett. 95 (2005) 075503.

Microfluidic Gas Flow Profiling Using Hyperpolarized Xenon and Remote Detection
C. Hilty, E. McDonnell, J. Granwehr, K. Pierce, S. Han, A. Pines, Proc. Nat. Acad. Sci. 102 (2005) 14960-14963.

Time Resolved Spectroscopic NMR Imaging Using Hyperpolarized 129-Xe
S. Han, H. Kühn, F. W. Häsing, K. Münnemann, B. Blümich, S. Appelt. J. Magn. Reson. 167 (2004) 298-305.

Imaging of a Mixture of Hyperpolarized He3 and Xe129
R.H. Acosta, P. Blümler, S. Han, S. Appelt, W. Häsing, J. Schmiedeskamp, W. Heil, H.W. Reson. Imag. 22 (2004) 1077-1083.

Proton Magnetic Resonance Imaging of Diffusion of High- and Low-Molecular-Weight Contrast Agents in Opaque Porous Media Saturated with Water
T. Osuga, S. Han. Magn. Reson. Imag. 22 (7) (2004) 1039-1042.

Three-Dimensional Phase-encoded Chemical Shift MRI in the Presence of Inhomogeneous Fields
V. Demas, D. Sakellariou, C. Meriles, S. Han, J. Reimer, A. Pines. Proc. Nat. Acad. Sci. 101 (24) (2004) 8845-8847.

Remotely-detected high-field MRI of Porous Samples
A. Seeley, S. Han, A. Pines. J. Magn. Reson. 167, 282-290 (2004).

Time Resolved Spectroscopic NMR Imaging Using Hyperpolarized 129-Xe
S. Han, H. Kühn, F. W. Häsing, K. Münnemann, B. Blümich, S. Appelt. J. Magn. Reson. 167, 298-305 (2004).

Remote Amplification of NMR Signal
A. J. Moule, M. Spence, S.-I Han, J.A. Seeley, K. Pierce, S. Saxena, A. Pines. Proc. Nat. Acad. Sci. 100 (16) (2003) 9122-9127.

Spectrally Resolved Velocity Exchange Spectroscopy of Two-Phase Flow
A. A. Khrapitchev, S.-I Han, S. Stapf, B. Blümich. J. Magn. Reson. 159, 36-45 (2002).

In Situ Observation of Diffusion and Reaction Dynamics in Gel Microreactors by Chemically Resolved NMR Microscopy
M. Küppers, C. Heine, S. Han, S. Stapf, B. Blümich. Appl. Magn. Reson. 22, 235-246 (2002).

Spatio-Temporal Correlations in Transport Processes Determined by Multi-PFG Experiments
S. Stapf, S. Han, C. Heine, B. Blümich. Concepts in Magn. Reson. 14 (3), 172-211 (2002).

NMR Imaging of Falling Drops
S. Han, S. Stapf, B. Blümich. Phys. Rev. Lett. 87 (14), 144501-144504 (2001).

Rheology of Blood by NMR
S. Han, O. Marseille, C. Gehlen, B. Blümich. J. Magn. Reson. 152 (2001) 87-94.

One-shot velocimetry using Echo Planar Imaging Microscopy
S. Han, P. T. Callaghan. J. Magn. Reson. 148 (2001) 349-354.

Two-Dimensional PFG-NMR for Encoding Correlations of Position, Velocity and Acceleration in Fluid Transport.
S. Han, S. Stapf, B. Blümich. J. Magn. Reson. 146, 169-180 (2000).

NMR Characterization of the Pore Structure and of Anisotropic Self-Diffusion in Salt Water Ice
M. I. Menzel, S. Han, S.Stapf, B. Blümich. J. Magn. Reson. 143, 376-381 (2000).

Two-Dimensional Representation of Position, Velocity and Acceleration by PFG-NMR
S. Han, B. Blümich. Appl. Magn. Reson. 18, 101-114 (2000).

2000–2006 Books and Book Chapters

Magnetic Resonance Imaging in Chemical Engineering
S. Stapf and S. Han.
Wiley-VCH, Weinheim, Germany (2006).

Fluid Flow and Trans-membrane Exchange in a Hemodialyzer Module
S. Han, S. Stapf.
in: S. Stapf, S. Han (Eds.) "NMR Imaging in Chemical Engineering" Wiley-VCH, Weinheim, Germany.

Broadening the application range of NMR and MRI by remote detection
S. Han, J. Granwehr, C. Hilty.
in: S. Stapf, S. Han (Eds.) "NMR Imaging in Chemical Engineering" Wiley-VCH, Weinheim, Germany.

2000–2006 Patents

Polarization Matrix for Producing Radical-Free Nuclear Spin Hyperpolarized Molecules as Contrast Agents.
S. Han, E.R. McCarney, B. D. Armstrong, M. D. Lingwood.
Provisional Patent (2006)

Remote NMR/MRI Detection of Laser Polarized Gases
Alex Pines, Sunil Saxena, Adam Moule, Megan Spence, Juliette Seeley, Kimberly Pierce, Song-I Han, Josef Grahnwehr
CIP U.S. Patent Application, IB-1771PCT, filed Oct. 9, 2002.